| Helicobacter pylori and refractory duodenal ulcers: cross-over comparison of continued cimetidine with cimetidine plus antimicrobials. | |
| | |
MedLine Citation:
|
PMID: 8079928 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: To determine the distribution of Helicobacter pylori in the antral and duodenal mucosa of patients with duodenal ulcers refractory to 12 wk of treatment with cimetidine and to evaluate the effect of adding antimicrobial agents to cimetidine on the healing of refractory duodenal ulcers. METHODS: A randomized crossover comparison of continued 800 mg of cimetidine at night for 4 wk with cimetidine plus 500 mg of amoxycillin three times a day for the first 2 wk and 250 mg of metronidazole three times a day for the second 2 wk. H. pylori status in the gastric antral and duodenal mucosa was evaluated by histology and bacterial culture before and at the end of each treatment period. RESULTS: Forty-eight patients were studied. Upon entry to the study, all patients had antral colonization with H. pylori. In the duodenum, active chronic duodenitis was present in 66%, duodenal gastric metaplasia in 33%, and H. pylori in 50%, similar proportions to patients with nonrefractory duodenal ulcers. Healing occurred in 70% (30 of 43) of patients during treatment with cimetidine plus antimicrobials but in only 21% (6 of 28) during treatment with cimetidine alone (p = 0.0003). In patients who received antimicrobials, neither clearance of H. pylori from the antrum (58% of patients) or duodenum (71% of colonized patients) nor eradication of H. pylori (33%) was significantly correlated with ulcer healing. CONCLUSIONS: The distribution of H. pylori in refractory duodenal ulcers is similar to nonrefractory ulcers, and the combination of amoxycillin and metronidazole with cimetidine increases the proportion of refractory duodenal ulcers, which heals. |
| | |
Authors:
|
H K Boyd; S Zaterka; J N Eisig; D Chinzon; K Iriya; A A Laudanna; E J Boyd |
Related Documents
:
|
2996118 - Intragastric bile acid concentrations in healthy subjects and in patients with gastric ... 7053458 - Leg ulcer. conservative management or surgical treatment? 12971258 - Evaluation of resection of the papilla of vater for the treatment of cancer in the papi... 19172458 - High prevalence of pulmonary hypertension in homozygous sickle cell patients with leg u... 15491038 - Ocular surface disorders and tear function changes in patients with chronic renal failure. 9850978 - Csf n-cam in neuroleptic-naïve first-episode patients with schizophrenia. |
Publication Detail:
|
Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: The American journal of gastroenterology Volume: 89 ISSN: 0002-9270 ISO Abbreviation: Am. J. Gastroenterol. Publication Date: 1994 Sep |
Date Detail:
|
Created Date: 1994-09-30 Completed Date: 1994-09-30 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0421030 Medline TA: Am J Gastroenterol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1505-10 Citation Subset: IM |
Affiliation:
|
Disciplina de Gastroenterologia Clinica, Faculdade de Medicina, Universidade de Sao Paulo, Brasil. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Amoxicillin / therapeutic use* Cimetidine / therapeutic use* Drug Administration Schedule Drug Therapy, Combination Duodenal Ulcer / drug therapy, epidemiology, microbiology* Female Follow-Up Studies Helicobacter Infections / drug therapy*, epidemiology Helicobacter pylori / isolation & purification* Humans Male Metronidazole / therapeutic use* Time Factors |
| Chemical | |
Reg. No./Substance:
|
26787-78-0/Amoxicillin; 443-48-1/Metronidazole; 51481-61-9/Cimetidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Triple therapy with sucralfate is not effective in eradicating Helicobacter pylori and does not redu...
Next Document: Effect of eradication of Helicobacter pylori on serum pepsinogen I, gastrin, and insulin in duodenal...