| Helicobacter pylori-positive duodenal ulcer: a long-term double-blind randomized study in patients healed with H2-receptor antagonists. | |
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MedLine Citation:
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PMID: 9398896 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The NIH Consensus Conference in 1994 (1) concluded that all patients with peptic ulcer disease should be tested and treated for Helicobacter pylori and that further evaluation was needed for patients in remission. MATERIALS AND METHODS: We evaluated in a double blind randomization 30 patients whose duodenal ulcers had been healed with H2-receptor antagonists and who remained in remission on maintenance therapy. After ulcer healing and the presence of H. pylori had been confirmed, these patients were randomized to receive eradication therapy or placebo and were followed for a mean period of 23 months. RESULTS: Almost all patients receiving placebo had ulcer recurrence, whereas the patients treated with antibiotics demonstrate a low recurrence rate. CONCLUSION: These data suggest, for the first time to our knowledge, the importance of treating with antibiotics duodenal ulcer patients whose disease is in remission. |
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Authors:
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R Suriani; M Ravizza; C Pallante; D Mazzucco; E Cardesi; M Colozza; M Malandrino; R Oneglio; G Orso Giacone; P Dusio; M Vajo |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Helicobacter Volume: 1 ISSN: 1083-4389 ISO Abbreviation: Helicobacter Publication Date: 1996 Sep |
Date Detail:
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Created Date: 1998-01-14 Completed Date: 1998-01-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9605411 Medline TA: Helicobacter Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 151-4 Citation Subset: IM |
Affiliation:
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Servizio di Endoscopia e di Microbiologia Ospedale di Rivoli, Torino, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antacids / administration & dosage, therapeutic use* Anti-Ulcer Agents / therapeutic use* Disease-Free Survival Double-Blind Method Doxycycline / administration & dosage, therapeutic use* Drug Therapy, Combination / administration & dosage, therapeutic use* Duodenal Ulcer / drug therapy*, etiology, microbiology, prevention & control Female Gastritis / complications*, drug therapy Helicobacter Infections / complications*, drug therapy Helicobacter pylori* Histamine H2 Antagonists / therapeutic use* Humans Life Tables Male Metronidazole / administration & dosage, therapeutic use* Middle Aged Organometallic Compounds / administration & dosage, therapeutic use* Ranitidine / therapeutic use* Recurrence Remission Induction |
| Chemical | |
Reg. No./Substance:
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0/Antacids; 0/Anti-Ulcer Agents; 0/Histamine H2 Antagonists; 0/Organometallic Compounds; 443-48-1/Metronidazole; 564-25-0/Doxycycline; 57644-54-9/bismuth tripotassium dicitrate; 66357-35-5/Ranitidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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