Document Detail

Helicobacter pylori, neutrophils, interleukins, and gastric epithelial proliferation.
MedLine Citation:
PMID:  9479648     Owner:  NLM     Status:  MEDLINE    
Infection of Helicobacter pylori causes chronic gastritis and plays an important role in the pathogenesis of gastroduodenal ulceration. H. pylori has also been suggested to be involved in the genesis of adenocarcincoma and MALT lymphoma of the stomach. H. pylori infection is associated with increased gastric epithelial proliferation, which can be reversed by a successful eradication of the organism. Although the mechanisms of increased gastric epithelial proliferation is not known, the enhanced epithelial proliferation is important in developing gastric carcinoma. Whether or not H. pylori de nove stimulates gastric epithelial proliferation is controversial, but gastric infection with H. pylori activates a mucosal inflammatory response by consisting of large numbers of polymorphonuclear and mononuclear cells, that also includes expression of various cytokines including interleukin-8. We review the mechanisms of H. pylori in enhanced gastric epithelial cell proliferation and cytokines in patients with H. pylori infection.
N Nakajima; H Kuwayama; Y Ito; A Iwasaki; Y Arakawa
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of clinical gastroenterology     Volume:  25 Suppl 1     ISSN:  0192-0790     ISO Abbreviation:  J. Clin. Gastroenterol.     Publication Date:  1997  
Date Detail:
Created Date:  1998-04-02     Completed Date:  1998-04-02     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7910017     Medline TA:  J Clin Gastroenterol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S198-202     Citation Subset:  IM    
Department of Medicine, Nihon University School of Medicine, Tokyo, Japan.
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MeSH Terms
Cytokines / metabolism*
Gastric Mucosa / microbiology,  pathology
Gastritis / microbiology*,  pathology
Helicobacter Infections / pathology*
Helicobacter pylori*
Interleukin-8 / metabolism*
Peptic Ulcer / microbiology*,  pathology
Stomach Neoplasms / microbiology*,  pathology
Reg. No./Substance:
0/Cytokines; 0/Interleukin-8

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