Document Detail


Helicobacter pylori may survive ampicillin treatment in the remnant stomach.
MedLine Citation:
PMID:  12139018     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Helicobacter pylori (H. pylori) is a Gram-negative curved rod-like or spiral bacterium that chronically infects the human gastric mucosa, and is a major risk factor for gastritis, gastric and duodenal ulcer and adenocarcinoma of the stomach. After partial gastrectomy, some patients may have persistent H. pylori infection for five years or more. In this study, we detected three bacteria, i.e., Klebsiella pneumoniae, Enterobacter aerogenes, and Escherichia coli, in the gastric juice of patients with a remnant stomach. Some of these bacteria produced beta-lactamase. These findings are potentially important since such bacteria could provide H. pylori with the chance to acquire drug resistance and to transfer drug resistance genes. This could be one reason why H. pylori is difficult to eradicate in the remnant stomach.
Authors:
Yoshio Hosaka; Ryoichi Okamoto; Kazuhiko Irinoda; Satoru Kaieda; Wasaburo Koizumi; Katunori Saigenji; Matsuhisa Inoue
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of antibiotics     Volume:  55     ISSN:  0021-8820     ISO Abbreviation:  J. Antibiot.     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-07-25     Completed Date:  2002-08-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0151115     Medline TA:  J Antibiot (Tokyo)     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  495-8     Citation Subset:  IM    
Affiliation:
Department of Microbiology, Kitasato University School of Medicine, Kanagawa, Japan. matsu@kitasato-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Ampicillin / pharmacology*
Culture Media
Enterobacter aerogenes / enzymology,  isolation & purification
Enterobacteriaceae Infections / microbiology
Escherichia coli / enzymology,  growth & development,  isolation & purification
Gastrectomy
Gastric Juice / microbiology*
Gastric Stump*
Helicobacter pylori / drug effects*,  enzymology,  growth & development*
Humans
Klebsiella pneumoniae / enzymology,  isolation & purification
Lactams / pharmacology*
Microbial Sensitivity Tests
beta-Lactam Resistance
Chemical
Reg. No./Substance:
0/Culture Media; 0/Lactams; 69-53-4/Ampicillin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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