| Helicobacter pylori infection and the pathogenesis of duodenal ulceration. | |
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MedLine Citation:
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PMID: 9928373 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Helicobacter pylori is a gram-negative spiral bacterium confined to the habitat of gastric-type epithelium. H. pylori causes duodenal ulceration by a cumulative effect of antral predominant gastritis with increased acid secretion, consequent gastric metaplasia in the duodenum (a site of further colonization by H. pylori), duodenitis, reduced duodenal bicarbonate secretion, and mucosal damage. Bacterial factors influence outcome. Major determinants are the production of a vacuolating toxin and the presence of CagA, an immunodominant product of a nonconserved gene cagA, a marker for the cag pathogenicity island that encodes virulence genes involved in induction of epithelial chemokine responses. In ulcer patients the mucosal immune response is polarized to a T-helper-1 (Th1) cell-mediated response, which may contribute to mucosal damage. Eradication of H. pylori restores acid output to normal. Loss of both acid and bacteria halts gastroduodenitis and allows ulcer healing. Gastric metaplasia does not regress in the short term. |
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Authors:
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M M Walker; J E Crabtree |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Annals of the New York Academy of Sciences Volume: 859 ISSN: 0077-8923 ISO Abbreviation: Ann. N. Y. Acad. Sci. Publication Date: 1998 Nov |
Date Detail:
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Created Date: 1999-02-24 Completed Date: 1999-02-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7506858 Medline TA: Ann N Y Acad Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 96-111 Citation Subset: IM; X |
Affiliation:
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Department of Histopathology, Imperial College School of Medicine at St Mary's, London, United Kingdom. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigens, Bacterial* Bacterial Proteins / genetics Duodenal Ulcer / microbiology, pathology, physiopathology* Duodenum / pathology Gastric Acid / secretion Gastric Mucosa / pathology Gastritis / etiology, microbiology, physiopathology Helicobacter Infections / complications, pathology, physiopathology* Helicobacter pylori* / genetics, pathogenicity Humans Intestinal Mucosa / microbiology, pathology Metaplasia Th1 Cells / immunology |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Bacterial; 0/Bacterial Proteins; 0/cagA protein, Helicobacter pylori |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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