Document Detail

Helicobacter pylori infection induces hyperammonaemia in Mongolian gerbils with liver cirrhosis.
MedLine Citation:
PMID:  11302955     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND AIMS: We previously reported the effect of Helicobacter pylori eradication on hyperammonaemia in patients with liver cirrhosis. However, the role of H pylori as a cause of hyperammonaemia is controversial. We developed an animal model with liver cirrhosis and investigated the effect of H pylori infection on hyperammonaemia. MATERIALS AND METHODS: Five week old male Mongolian gerbils were inoculated orally with broth culture of H pylori. Forty eight gerbils were divided into four groups. Gerbils not inoculated with H pylori were fed a commercial rodent diet (group A) or a choline deficient diet (group C). Gerbils inoculated with H pylori were fed the commercial rodent diet (group B) or the choline deficient diet (group D). Blood ammonia levels of the femoral vein and portal vein were measured 30 weeks later. RESULTS: All gerbils fed the choline deficient diet developed liver cirrhosis with fatty metamorphosis. The survival rate of group D was significantly lower than that of the other groups. Systemic and portal blood ammonia levels in group D were significantly higher than those in the other groups. CONCLUSIONS: H pylori infection induces hyperammonaemia in gerbils with liver cirrhosis.
H Suto; T Azuma; S Ito; M Ohtani; M Dojo; Y Ito; Y Kohli; M Kuriyama
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gut     Volume:  48     ISSN:  0017-5749     ISO Abbreviation:  Gut     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-04-16     Completed Date:  2001-05-17     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  England    
Other Details:
Languages:  eng     Pagination:  605-8     Citation Subset:  AIM; IM    
Second Department of Internal Medicine, Faculty of Medicine, Fukui Medical University, Fukui, Japan.
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MeSH Terms
Choline Deficiency
Helicobacter Infections / complications*,  metabolism,  pathology
Helicobacter pylori*
Hepatic Encephalopathy / etiology
Hyperammonemia / etiology*,  metabolism,  pathology
Liver Cirrhosis, Experimental / complications*,  metabolism,  pathology
Models, Animal*
Comment In:
Gut. 2001 May;48(5):590-1   [PMID:  11302949 ]

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