| Helicobacter pylori infection induces hyperammonaemia in Mongolian gerbils with liver cirrhosis. | |
| | |
MedLine Citation:
|
PMID: 11302955 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND AND AIMS: We previously reported the effect of Helicobacter pylori eradication on hyperammonaemia in patients with liver cirrhosis. However, the role of H pylori as a cause of hyperammonaemia is controversial. We developed an animal model with liver cirrhosis and investigated the effect of H pylori infection on hyperammonaemia. MATERIALS AND METHODS: Five week old male Mongolian gerbils were inoculated orally with broth culture of H pylori. Forty eight gerbils were divided into four groups. Gerbils not inoculated with H pylori were fed a commercial rodent diet (group A) or a choline deficient diet (group C). Gerbils inoculated with H pylori were fed the commercial rodent diet (group B) or the choline deficient diet (group D). Blood ammonia levels of the femoral vein and portal vein were measured 30 weeks later. RESULTS: All gerbils fed the choline deficient diet developed liver cirrhosis with fatty metamorphosis. The survival rate of group D was significantly lower than that of the other groups. Systemic and portal blood ammonia levels in group D were significantly higher than those in the other groups. CONCLUSIONS: H pylori infection induces hyperammonaemia in gerbils with liver cirrhosis. |
| | |
Authors:
|
H Suto; T Azuma; S Ito; M Ohtani; M Dojo; Y Ito; Y Kohli; M Kuriyama |
Related Documents
:
|
8648445 - Dietary choline requirement of juvenile red drum (sciaenops ocellatus). 21475675 - Wasting in chronic kidney disease. 21187125 - Maternal high-fat intake alters presynaptic regulation of dopamine in the nucleus accum... 22967195 - Explaining the effects of a point-of-purchase nutrition-information intervention in uni... 9001695 - Effects of colostrum feeding on intestinal development in newborn pigs. 11934435 - Dietary modulation of mitochondrial dna deletions and copy number after chemotherapy in... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Gut Volume: 48 ISSN: 0017-5749 ISO Abbreviation: Gut Publication Date: 2001 May |
Date Detail:
|
Created Date: 2001-04-16 Completed Date: 2001-05-17 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 2985108R Medline TA: Gut Country: England |
Other Details:
|
Languages: eng Pagination: 605-8 Citation Subset: AIM; IM |
Affiliation:
|
Second Department of Internal Medicine, Faculty of Medicine, Fukui Medical University, Fukui, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Choline Deficiency Gerbillinae Helicobacter Infections / complications*, metabolism, pathology Helicobacter pylori* Hepatic Encephalopathy / etiology Hyperammonemia / etiology*, metabolism, pathology Liver Cirrhosis, Experimental / complications*, metabolism, pathology Male Models, Animal* Prognosis |
| Comments/Corrections | |
Comment In:
|
Gut. 2001 May;48(5):590-1
[PMID:
11302949
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Helicobacter pylori infection induced alteration of gene expression in human gastric cells.
Next Document: Absence of endogenous interleukin 10 enhances early stress response during post-ischaemic injury in ...