Document Detail

Helicobacter pylori infection induces a decrease in immunoreactive-somatostatin concentrations of human stomach.
MedLine Citation:
PMID:  1346517     Owner:  NLM     Status:  MEDLINE    
Immunoreactive-somatostatin (ir-somatostatin) concentrations of the gastric mucosa and gastric juice with Helicobacter pylori infection were measured in the human stomach. One hundred seventy-one patients (106 males, 65 females; mean age, 52.0; range, 19-84 years) were registered. Gastric juice and mucosa were obtained with the usual endoscopy procedure. Somatostatin concentration was measured by radioimmunoassay. The ir-somatostatin concentrations in the H. pylori-negative group were significantly higher than in the positive group gastric mucosa, whereas its levels in gastric juice tended to decrease with H. pylori infection. There was an inverse correlation between luminal ammonia levels and ir-somatostatin concentrations of the gastric mucosa. On the other hand, ir-somatostatin concentrations of the gastric mucosa significantly decreased with chronic and active inflammatory change. This decrease was not correlated with the grade of active inflammation, which was in close relation to H. pylori infection, but with the grade of chronic inflammation. These results indicate that H. pylori may reduce ir-somatostatin concentrations of the human stomach and that its effect is partly mediated via luminal ammonia produced by H. pylori.
H Kaneko; K Nakada; T Mitsuma; K Uchida; A Furusawa; Y Maeda; K Morise
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  37     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  1992 Mar 
Date Detail:
Created Date:  1992-03-12     Completed Date:  1992-03-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  409-16     Citation Subset:  AIM; IM    
Fourth Department of Internal Medicine, Aichi Medical University, Japan.
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MeSH Terms
Aged, 80 and over
Ammonia / analysis
Gastric Acidity Determination
Gastric Juice / metabolism*
Gastric Mucosa / metabolism*
Gastritis / metabolism*
Helicobacter Infections / metabolism*
Middle Aged
Multivariate Analysis
Somatostatin / metabolism*
Reg. No./Substance:
51110-01-1/Somatostatin; 7664-41-7/Ammonia

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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