| Helicobacter pylori infection in hemodialysis patients. | |
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MedLine Citation:
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PMID: 14696511 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/AIMS: Studies on the relationship between high serum urea nitrogen, creatinine and Helicobacter pylori infection in hemodialysis patients still give conflicting results. In the present study we investigated the prevalence of Helicobacter pylori positivity in patients with hemodialysis [HD(+)] and without hemodialysis [HD(-)] and assessed the relationship between clinical factors, serum urea nitrogen, creatinine levels and Helicobacter pylori prevalence in these patients. METHODOLOGY: 117 patients with dyspeptic complaints were included in the study. They consisted of 36 HD(+) patients (31%) and 81 HD(-) patients (69%). Endoscopy was performed and gastric antral biopsies were obtained for immunohistochemical analysis for Helicobacter pylori in all patients. RESULTS: Helicobacter pylori was positive in 53(45%) of 117 patients [Hp(+)]. In univariate analysis Hp(+) patients received hemodialysis therapy significantly less often (P = 0.002) and had lower serum urea nitrogen (P = 0.0008) and creatinine (P = 0.003) levels than Hp(-) patients. There was no significant difference in age, gender, endoscopic findings or comorbid conditions (hypertension or diabetes mellitus) between these groups. Multivariate logistic regression analysis revealed that only the serum urea nitrogen level was significantly associated with Helicobacter pylori prevalence (P = 0.008). CONCLUSIONS: These results indicate that high serum urea nitrogen seems to correlate with a low prevalence of Helicobacter pylori infection and hemodialysis patients with high serum urea nitrogen may be protected against Helicobacter pylori infection. |
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Authors:
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Katsuhiko Tsukada; Tatsuya Miyazaki; Hiroyuki Katoh; Minako Yoshikawa; Norihiro Masuda; Hitoshi Ojima; Kohei Tajima; Yasuyuki Fukai; Masanobu Nakajima; Youichi Kamiyama; Hiroyuki Kuwano; Osamu Tsukada |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Hepato-gastroenterology Volume: 50 ISSN: 0172-6390 ISO Abbreviation: Hepatogastroenterology Publication Date: 2003 Nov-Dec |
Date Detail:
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Created Date: 2003-12-30 Completed Date: 2004-06-15 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8007849 Medline TA: Hepatogastroenterology Country: Greece |
Other Details:
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Languages: eng Pagination: 2255-8 Citation Subset: IM |
Affiliation:
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Department of First Surgery, Gunma University School of Medicine 3-39-22 Showamachi Maebashi, 371-8511 Japan. katukada@topaz.ocn.ne.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Biopsy Blood Urea Nitrogen* Creatinine / blood* Cross-Sectional Studies Diagnosis, Differential Duodenitis / diagnosis*, epidemiology Dyspepsia / etiology Female Gastric Mucosa / pathology Gastritis / diagnosis*, epidemiology Helicobacter Infections / diagnosis*, epidemiology Helicobacter pylori* Humans Japan Kidney Failure, Chronic / epidemiology, therapy* Male Middle Aged Odds Ratio Renal Dialysis* / statistics & numerical data Risk Factors |
| Chemical | |
Reg. No./Substance:
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60-27-5/Creatinine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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