Document Detail

Helicobacter pylori infection in coronary artery disease.
MedLine Citation:
PMID:  17033109     Owner:  NLM     Status:  MEDLINE    
The role of inflammation in the pathogenesis and progression of coronary artery disease (CAD) has been increasingly discussed, but still remains unclear. Inflammatory changes in the vessel wall play an important role in the pathogenesis of atherosclerosis. Systemic inflammatory reaction can be detected by showing increased plasma levels of different proinflammatory cytokines and acute-phase proteins. Infectious agents have been linked to coronary heart disease on epidemiological and pathogenetic grounds. The prevalent condition and the exact mechanism of initiation of atherosclerotic vascular disease remain unclear. Nevertheless, many similarities exist between the processes of inflammation and atherogenesis, and the evidence is growing for the role of an active inflammation in the atherosclerosis in the coronary circulation and elsewhere. Although the seroepidemiological and eradication studies have suggested a causal relationship between Helicobacter pylori (Hp) infection and coronary heart disease; the issue is still controversial. The detection of Hp specific DNA in atheromatous plaque material from coronary arteries, but more important, the reduction in restenosis of coronary vessels after Hp eradication could be interpreted as an evidence for the involvement of a Hp infection in the progression of CAD induced by a local inflammatory process.
M Kowalski; M Pawlik; J W Konturek; S J Konturek
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society     Volume:  57 Suppl 3     ISSN:  1899-1505     ISO Abbreviation:  J. Physiol. Pharmacol.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-10-11     Completed Date:  2008-01-03     Revised Date:  2008-05-19    
Medline Journal Info:
Nlm Unique ID:  9114501     Medline TA:  J Physiol Pharmacol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  101-11     Citation Subset:  IM    
Schüchterman - Klinik, Heart - Center Osnabrück - Bad Rothenfelde, Witten/Herdecke - University, Germany.
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MeSH Terms
Coronary Artery Disease / blood,  epidemiology*,  microbiology
Coronary Vessels / microbiology
DNA, Bacterial / genetics
Helicobacter Infections / blood,  epidemiology*,  microbiology
Helicobacter pylori* / genetics
Reg. No./Substance:
0/DNA, Bacterial

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