Document Detail

Helicobacter pylori-induced alteration of epithelial cell signaling and polarity: a possible mechanism of gastric carcinoma etiology and disparity.
MedLine Citation:
PMID:  23629919     Owner:  NLM     Status:  MEDLINE    
Gastric cancer, a disease of disparity associated with Helicobacter pylori (H. pylori) infection, is the world's second leading cause of cancer deaths. The pathogen H. pylori target the epithelial adhesion receptors, E-cadherin, and β1-integrin, to modulate the host cytoskeleton via disruption of the epithelial cell polarity necessary for maintaining the infection, but how this leads to the development of the carcinoma is widely unclear. While Rho family GTPases' signaling to the cytoskeleton and these receptors is required for initiating and maintaining the infection, the responsible effectors, and how they might influence the etiology of the carcinomas are currently unknown. Here we discuss the potential role of the Cdc42-IQGAP1 axis, a negative regulator of the tumor suppressors E-cadherin and β1-integrin, as a potential driver of H. pylori-induced gastric carcinoma and propose avenues for addressing its disparity. Chronic dysfunction of the IQGAP1-signaling pathway, resulting from H. pylori-induced disruption of cell polarity, can explain the pathogenesis of the carcinoma, at least, in subsets of infected population, and thus could provide a potential means for personalized medicine.
Mahasin A Osman; George S Bloom; Emmanuel A Tagoe
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2013-07-03
Journal Detail:
Title:  Cytoskeleton (Hoboken, N.J.)     Volume:  70     ISSN:  1949-3592     ISO Abbreviation:  Cytoskeleton (Hoboken)     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-07-23     Completed Date:  2014-02-06     Revised Date:  2014-07-24    
Medline Journal Info:
Nlm Unique ID:  101523844     Medline TA:  Cytoskeleton (Hoboken)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  349-59     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Wiley Periodicals, Inc.
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MeSH Terms
Cell Communication / physiology*
Cell Polarity / physiology
Epithelial Cells / microbiology,  pathology
Helicobacter Infections / microbiology*,  pathology*
Helicobacter pylori / physiology*
Stomach Neoplasms / microbiology*,  pathology*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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