| Helicobacter pylori in Thai patients with cholangiocarcinoma and its association with biliary inflammation and proliferation. | |
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MedLine Citation:
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PMID: 22321036 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Objectives: To investigate whether Helicobacter spp. infection and the cagA of H. pylori are associated with hepatobiliary pathology, specifically biliary inflammation, cell proliferation and cholangiocarcinoma (CCA). Methods: Helicobacter species including H. pylori, H. bilis and H. hepaticus were detected in the specimens using the polymerase chain reaction (PCR). Biliary inflammation of the liver and gallbladders was semi-quantitatively graded on hematoxylin and eosin (H&E)-stained slides. Biliary proliferation was evaluated by immunohistochemistry using the Ki-67-labelling index. Results: Helicobacter pylori was found in 66.7%, 41.5% and 25.0% of the patients in the CCA, cholelithiasis and control groups (P < 0.05), respectively. By comparison, H. bilis was found in 14.9% and 9.4% of the patients with CCA and cholelithiasis, respectively (P > 0.05), and was absent in the control group. The cagA gene of H. pylori was detected in 36.2% and 9.1% of the patients with CCA and cholelithiasis, respectively (P < 0.05). Among patients with CCA, cell inflammation and proliferation in the liver and gallbladder were significantly higher among those DNA H. pylori positive than negative. Conclusions: The present findings suggest that H. pylori, especially the cagA-positive strains, may be involved in the pathogenesis of hepatobiliary diseases, especially CCA through enhanced biliary cell inflammation and proliferation. |
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Authors:
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Wongwarut Boonyanugomol; Chariya Chomvarin; Banchob Sripa; Vajarabhongsa Bhudhisawasdi; Narong Khuntikeo; Chariya Hahnvajanawong; Amporn Chamsuwan |
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Publication Detail:
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Type: Journal Article Date: 2012-01-10 |
Journal Detail:
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Title: HPB : the official journal of the International Hepato Pancreato Biliary Association Volume: 14 ISSN: 1477-2574 ISO Abbreviation: HPB (Oxford) Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-02-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100900921 Medline TA: HPB (Oxford) Country: England |
Other Details:
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Languages: eng Pagination: 177-84 Citation Subset: IM |
Copyright Information:
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© 2012 International Hepato-Pancreato-Biliary Association. |
Affiliation:
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Department of Microbiology Department of Pathology Department of Surgery Department of Forensic Medicine Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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