Document Detail


Helicobacter pylori in Africa: observations on an 'enigma within an enigma'.
MedLine Citation:
PMID:  10535465     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: We conducted a retrospective literature review of all the data published on Helicobacter pylori in Africa in order to test whether the prevalence of diseases associated with this organism differs from that in developed nations. METHODS: Both sero-epidemiological (n = 8) as well as prospective endoscopic studies in subjects with either dyspepsia or epigastric pain (n = 23) and one retrospective study were available for analysis. RESULTS: Sero-epidemiology confirmed both the early age of acquisition in children (50% by 10 years) as well as the high prevalence of the organism (61%) in adult asymptomatic individuals. Endoscopic studies in dyspeptic individuals revealed the presence of the organism in 72%. Duodenal ulceration was noted in 26% of 3473 cases and in these, H. pylori was present in 90%. An association of gastric metaplasia with duodenal ulceration was identified in the one study in which it was investigated. Gastric ulceration occurred approximately four-fold less frequently (7% of 2286 cases) than duodenal ulceration and the organism was evident in 75% of the gastric ulceration cases. Findings of intestinal metaplasia (14%) and gastric cancer (3.4%) were not infrequent, but the paucity of accurate epidemiological data made it difficult to establish a correlation between the two. CONCLUSION: It would appear that prospective endoscopic-based studies in African subjects may question the standard dogma of a low prevalence of H. pylori-associated diseases in Africa. Further research is clearly required.
Authors:
M Kidd; J A Louw; I N Marks
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of gastroenterology and hepatology     Volume:  14     ISSN:  0815-9319     ISO Abbreviation:  J. Gastroenterol. Hepatol.     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-11-18     Completed Date:  1999-11-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8607909     Medline TA:  J Gastroenterol Hepatol     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  851-8     Citation Subset:  IM    
Affiliation:
Department of Medicine, University of Cape Town and Groote Schuur Hospital Observatory, South Africa.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Africa / epidemiology
Child
Child, Preschool
Dyspepsia / epidemiology,  microbiology,  pathology
Endoscopy, Gastrointestinal
Gastritis / epidemiology,  microbiology,  pathology
Gastrointestinal Diseases / epidemiology*,  microbiology*,  pathology
Gastrointestinal Neoplasms / epidemiology,  microbiology,  pathology
Helicobacter Infections / diagnosis*,  epidemiology*,  immunology
Helicobacter pylori / immunology*
Humans
Infant
Middle Aged
Peptic Ulcer / epidemiology,  microbiology,  pathology
Retrospective Studies
Seroepidemiologic Studies
Statistics, Nonparametric

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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