| Helicobacter pylori, gastrointestinal symptoms, and metabolic control in young type 1 diabetes mellitus patients. | |
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MedLine Citation:
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PMID: 12671115 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The role of Helicobacter pylori infection in metabolic control and gastrointestinal symptoms in type 1 diabetes mellitus (DM1) patients has been debated. The aim of this study was to investigate the prevalence of H pylori, of the more cytotoxic Cag-A-positive strains, and the effects of infection on gastrointestinal symptoms and metabolic control in young DM1 patients. Research Design and Methods. H pylori infection was investigated by using the 13C-urea breath test in 121 DM1 patients (65 males, 56 females; mean age: 15 +/- 6 years) and 147 matched controls. In positive patients, an assay for specific immunoglobulin G against Cag-A was performed. Glycosylated hemoglobin A, daily insulin requirement, and duration of illness were established; a questionnaire concerning the presence of dyspeptic symptoms was administered. RESULTS: No difference in H pylori infection rate between patients and controls was observed. Thirty-four (28.1%) of 121 patients and 43 (29.25%) of 147 controls were infected. Twenty-one patients and 24 controls were positive for Cag-A. Glycosylated hemoglobin A, daily insulin requirement, and duration of illness were not affected by infection nor by Cag-A status. Among gastrointestinal symptoms, only halitosis was related to H pylori infection, but this association disappeared after correction for age. Positive patients with halitosis showed a worse glycemic control than uninfected patients with halitosis. CONCLUSIONS: H pylori infection and Cag-A-positive strains do not affect metabolic control in DM1 patients. With regard to gastrointestinal symptoms studied, H pylori infection, when present in participants with halitosis, seems to predict a worse metabolic control than in H pylori-negative patients with halitosis. |
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Authors:
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Marcello Candelli; Donato Rigante; Giovanni Marietti; Enrico C Nista; Francesca Crea; Francesco Bartolozzi; Alessandra Schiavino; Giulia Pignataro; Nicoló Gentiloni Silveri; Giovanni Gasbarrini; Antonio Gasbarrini |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pediatrics Volume: 111 ISSN: 1098-4275 ISO Abbreviation: Pediatrics Publication Date: 2003 Apr |
Date Detail:
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Created Date: 2003-04-02 Completed Date: 2003-04-18 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0376422 Medline TA: Pediatrics Country: United States |
Other Details:
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Languages: eng Pagination: 800-3 Citation Subset: AIM; IM |
Affiliation:
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Department of Internal Medicine, Catholic University, Rome, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Antigens, Bacterial / analysis, immunology Bacterial Proteins / analysis, immunology Breath Tests / methods Carbon Radioisotopes / analysis Child Diabetes Mellitus, Type 1 / complications, metabolism*, microbiology*, urine Female Gastrointestinal Diseases / metabolism*, microbiology*, urine Halitosis / metabolism, microbiology, urine Helicobacter Infections / complications, epidemiology, metabolism*, urine Helicobacter pylori* / isolation & purification Hemoglobin A, Glycosylated / metabolism Hemoglobinuria / metabolism, microbiology Humans Male Predictive Value of Tests Prevalence Questionnaires Socioeconomic Factors Urea / analysis |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Bacterial; 0/Bacterial Proteins; 0/Carbon Radioisotopes; 0/Hemoglobin A, Glycosylated; 0/cagA protein, Helicobacter pylori; 57-13-6/Urea |
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