Document Detail

Helicobacter pylori and gastric diseases: a dangerous association.
MedLine Citation:
PMID:  15312678     Owner:  NLM     Status:  MEDLINE    
The bacterium Helicobacter pylori is linked to the appearance of several gastric diseases and in particular is associated with a progression to gastric cancer. Thistrun -1 bacterium colonizes the gastric mucosa directly interacting with epithelial cells. It is well known that H. pylori is associated with alterations in the gastric epithelial cell cycle, and apoptosis, higher levels of mononuclear and neutrophilic infiltrates, more severe atrophy and intestinal metaplasia. In last years, two mechanisms that interact with each other or not have been proposed: the hyperproliferation of gastric cells and oxidative damage of stomach mucosa. In particular, cell cycle alterations induce mitogenic signals and proto-oncogene expression that may trigger the development of cancer. Contemporary, H. pylori is able to induce polymorphonuclear and mononuclear cells that produce oxygen free radicals that could cause DNA damage to the adjacent cells leading to cancer development. Due to dangerous infection of this bacterium, the scientific community must point out its attention on the development of detection and prevention strategies.
Antonio De Luca; Gaetano Iaquinto
Related Documents :
7502528 - The consequences of hypergastrinemia.
3428858 - Gastric mucosal cell loss caused by aspirin and alcohol.
22481568 - Functional screening of intracardiac cell transplants using two-photon fluorescence mic...
1127018 - Isolation and separation of highly enriched fractions of viable mouse gastric parietal ...
8392508 - Myometrial characteristics of the syrian hamster uterine smooth muscle cell line, shm.
24508728 - Activated alveolar epithelial cells initiate fibrosis through autocrine and paracrine s...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Cancer letters     Volume:  213     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-08-17     Completed Date:  2004-10-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  1-10     Citation Subset:  IM    
Department of Medicine and Public Health, Section of Clinical Anatomy, Second University of Naples, Naples, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cell Cycle
Cell Transformation, Neoplastic
DNA Damage*
Gastric Mucosa / cytology,  immunology,  microbiology,  pathology
Gene Expression Regulation
Helicobacter Infections / complications*
Helicobacter pylori / pathogenicity*
Oxidative Stress
Signal Transduction
Stomach Neoplasms / microbiology*,  physiopathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  MHC class I manipulation on cell surfaces by gene transfer of anti-MHC class I intrabodies--a tool f...
Next Document:  Disease-related potential of mutations in transcriptional cofactors CREB-binding protein and p300 in...