Document Detail


Helicobacter pylori and gastric diseases: a dangerous association.
MedLine Citation:
PMID:  15312678     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The bacterium Helicobacter pylori is linked to the appearance of several gastric diseases and in particular is associated with a progression to gastric cancer. Thistrun -1 bacterium colonizes the gastric mucosa directly interacting with epithelial cells. It is well known that H. pylori is associated with alterations in the gastric epithelial cell cycle, and apoptosis, higher levels of mononuclear and neutrophilic infiltrates, more severe atrophy and intestinal metaplasia. In last years, two mechanisms that interact with each other or not have been proposed: the hyperproliferation of gastric cells and oxidative damage of stomach mucosa. In particular, cell cycle alterations induce mitogenic signals and proto-oncogene expression that may trigger the development of cancer. Contemporary, H. pylori is able to induce polymorphonuclear and mononuclear cells that produce oxygen free radicals that could cause DNA damage to the adjacent cells leading to cancer development. Due to dangerous infection of this bacterium, the scientific community must point out its attention on the development of detection and prevention strategies.
Authors:
Antonio De Luca; Gaetano Iaquinto
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Cancer letters     Volume:  213     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-08-17     Completed Date:  2004-10-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  1-10     Citation Subset:  IM    
Affiliation:
Department of Medicine and Public Health, Section of Clinical Anatomy, Second University of Naples, Naples, Italy.
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MeSH Terms
Descriptor/Qualifier:
Cell Cycle
Cell Transformation, Neoplastic
DNA Damage*
Gastric Mucosa / cytology,  immunology,  microbiology,  pathology
Gene Expression Regulation
Helicobacter Infections / complications*
Helicobacter pylori / pathogenicity*
Humans
Inflammation
Oxidative Stress
Proto-Oncogenes
Signal Transduction
Stomach Neoplasms / microbiology*,  physiopathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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