Document Detail


Helicobacter pylori eradication with short-term therapy leads to duodenal ulcer healing without the need for continued acid suppression therapy.
MedLine Citation:
PMID:  8804868     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine whether duodenal ulcers continue to heal following successful Helicobacter pylori eradication with short-term eradication therapy without further acid suppression therapy. METHODS: Patients with endoscopically proven duodenal ulcers who were H. pylori positive were randomized to receive omeprazole 40 mg each morning and clarithromycin 500 mg three times daily or famotidine 40 mg twice daily and clarithromycin 500 mg three times daily for 2 weeks. No acid-suppressing agents nor ulcerhealing drugs such as bismuth compounds or sucralfate were prescribed after that. Patients were re-examined endoscopically at week 2 at the end of treatment, and at week 6, 4 weeks after the completion of treatment. RESULTS: Thirty of 44 (68.2%) patients from both treatment arms, in whom the bacteria were subsequently noted to have been eradicated, had healed ulcers at week 2; at Week 6, 42 of 44 (95.5%) were noted to have healed ulcers without further acid-suppressing or ulcer-healing treatment. CONCLUSION: Although a short-term acid-suppressing treatment is insufficient to heal ulcers, where an important putative factor such as H. pylori is eliminated, the ulcer healing process continues without further need for acid-suppressing or ulcer-healing agents.
Authors:
K L Goh; P Navaratnam; S C Peh; N W Wong; S Y Chuah; N A Rahman; Y L Lo
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of gastroenterology & hepatology     Volume:  8     ISSN:  0954-691X     ISO Abbreviation:  Eur J Gastroenterol Hepatol     Publication Date:  1996 May 
Date Detail:
Created Date:  1997-01-24     Completed Date:  1997-01-24     Revised Date:  2009-10-16    
Medline Journal Info:
Nlm Unique ID:  9000874     Medline TA:  Eur J Gastroenterol Hepatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  421-3     Citation Subset:  IM    
Affiliation:
Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Anti-Bacterial Agents / therapeutic use*
Anti-Ulcer Agents / therapeutic use*
Clarithromycin / therapeutic use
Drug Therapy, Combination
Duodenal Ulcer / drug therapy*,  microbiology*
Famotidine / therapeutic use
Female
Helicobacter Infections / drug therapy*
Helicobacter pylori*
Humans
Male
Middle Aged
Omeprazole / therapeutic use
Proton Pumps / antagonists & inhibitors
Treatment Outcome
Wound Healing
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Anti-Ulcer Agents; 0/Proton Pumps; 73590-58-6/Omeprazole; 76824-35-6/Famotidine; 81103-11-9/Clarithromycin
Comments/Corrections
Comment In:
Eur J Gastroenterol Hepatol. 1996 May;8(5):415-6   [PMID:  8804866 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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