| Helicobacter pylori eradication: proton pump inhibitor vs. ranitidine bismuth citrate plus two antibiotics for 1 week-a meta-analysis of efficacy. | |
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MedLine Citation:
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PMID: 10971230 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To compare the efficacy of proton pump inhibitor vs. ranitidine bismuth citrate (RBC) with two antibiotics for 1 week in Helicobacter pylori eradication. METHODS: Randomized trials comparing 1-week regimens with (i) proton pump inhibitor plus two antibiotics [clarithromycin (C) and amoxycillin (A) or a nitroimidazole (N)]; or (ii) RBC plus the same antibiotics. Eradication was confirmed by histology or 13C-urea breath test at least 4 weeks after therapy. Data sources included PubMed database and abstracts from congresses until October 1999. Statistical analysis was by meta-analysis combining the odds ratios (OR) of the individual studies in a global OR (Peto method). RESULTS: Twelve studies met the selection criteria. Nine compared proton pump inhibitor vs. RBC plus C and A, and five compared proton pump inhibitor vs. RBC plus C and N. With RBC, C and A, mean H. pylori eradication efficacy by intention-to-treat analysis (pooled data) was 76.6% (95% CI: 72-81%) and 73.7% (95% CI: 69-78%) with proton pump inhibitor, C and A. The OR for the effect of RBC vs. proton pump inhibitor (plus C and A) on H. pylori eradication was 1.15 (95% CI: 0.8-1.64%). Mean H. pylori eradication with RBC, C and N was 87. 2% (95% CI: 83-91%), and 74.9% (95% CI: 74-84%) with proton pump inhibitor plus these two antibiotics. The OR for the effect of RBC vs. proton pump inhibitor (plus C and N) on H. pylori eradication was 1.76 (95% CI: 1.08-2.85%). CONCLUSION: RBC and proton pump inhibitor have similar efficacy for H. pylori eradication when given with C and A for 1 week, but RBC seems to have a higher efficacy than proton pump inhibitor when C and N are the co-prescribed antibiotics. |
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Authors:
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J P Gisbert; L González; X Calvet; M Roqué; R Gabriel; J M Pajares |
Publication Detail:
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Type: Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Alimentary pharmacology & therapeutics Volume: 14 ISSN: 0269-2813 ISO Abbreviation: Aliment. Pharmacol. Ther. Publication Date: 2000 Sep |
Date Detail:
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Created Date: 2000-10-19 Completed Date: 2000-10-19 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8707234 Medline TA: Aliment Pharmacol Ther Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1141-50 Citation Subset: IM |
Affiliation:
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Department of Gastroenterology, University Hospital of 'La Princesa', Madrid, Spain. gisbert@meditex.es |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amoxicillin
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administration & dosage,
therapeutic use* Anti-Bacterial Agents / administration & dosage, therapeutic use* Anti-Ulcer Agents / administration & dosage, therapeutic use* Bismuth / administration & dosage, therapeutic use* Clarithromycin / administration & dosage, therapeutic use* Drug Therapy, Combination Helicobacter Infections / drug therapy* Helicobacter pylori / drug effects* Humans Nitroimidazoles / administration & dosage, therapeutic use* Proton Pumps / antagonists & inhibitors* Randomized Controlled Trials as Topic Ranitidine / administration & dosage, analogs & derivatives*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Anti-Ulcer Agents; 0/Nitroimidazoles; 0/Proton Pumps; 128345-62-0/ranitidine bismuth citrate; 26787-78-0/Amoxicillin; 66357-35-5/Ranitidine; 7440-69-9/Bismuth; 81103-11-9/Clarithromycin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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