Document Detail

Helicobacter pylori eradication does not influence gastroesophageal reflux disease: a prospective, parallel, randomized, open-label, controlled trial.
MedLine Citation:
PMID:  22481687     Owner:  NLM     Status:  In-Data-Review    
CONTEXT: Helicobacter pylori has been associated with worsening of gastroesophageal reflux disease (GERD).
OBJECTIVE: To evaluate the effect of H. pylori eradication in GERD patients.
METHODS: We conducted a prospective, randomized, controlled trial performing symptom evaluation, endoscopy, histology, manometry and esophageal pH testing on GERD patients. Patients infected with H. pylori were randomized to: 1) eradication treatment plus proton pump inhibitors treatment, or 2) proton pump inhibitors alone. Patients not infected constituted a negative control group. After 3 months, patients were re-evaluated by symptom assessment, endoscopy, histology and manometry.
RESULTS: GERD treatment resulted in significantly higher lower esophageal sphincter pressure, as measured by mean expiratory pressure, in H. pylori negative patients. There was significantly lower proportion of hypotensive waves and significantly higher proportion of normotensive waves in non-eradicated patients. All symptom scores were significantly reduced in the post-treatment period compared to baseline, to values that were similar among the three groups, in the post-treatment period. In the post-treatment period, erosive esophagitis was significantly less frequent on those not eradicated.
CONCLUSION: Manometric, clinical and endoscopic data showed no benefit in eradicating H. pylori in GERD. Our data supports the hypothesis that H. pylori eradication does not influence GERD.
Lino Rodrigues; Cintya Miler de Faria; Stephan Geocze; Luiz Chehter
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Arquivos de gastroenterologia     Volume:  49     ISSN:  1678-4219     ISO Abbreviation:  Arq Gastroenterol     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-04-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  15310600R     Medline TA:  Arq Gastroenterol     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  56-63     Citation Subset:  IM    
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