| Helicobacter pylori-derived neutrophil-activating protein increases the lifespan of monocytes and neutrophils. | |
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MedLine Citation:
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PMID: 20070310 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An invariable feature of Helicobacter pylori-infected gastric mucosa is the persistent infiltration of inflammatory cells. The neutrophil-activating protein (HP-NAP) has a pivotal role in triggering and orchestrating the phlogistic process associated with H. pylori infection. Aim of this study was to address whether HP-NAP might further contribute to the inflammation by increasing the lifespan of inflammatory cells. We report that HP-NAP is able to prolong the lifespan of monocytes, in parallel with the induction of the anti-apoptotic proteins A1, Mcl-1, Bcl-2 and Bcl-X(L). This effect does not result from a direct action on the apoptotic machinery, but rather it requires the release of endogenous pro-survival factors, such as interleukin-1beta, which probably acts in synergy with other unidentified mediators. We also report that HP-NAP promotes the survival of Ficoll-purified neutrophils in a monocyte-dependent fashion: indeed, mononuclear cell depletion of Ficoll-purified neutrophils completely abolished the pro-survival effect by HP-NAP. In conclusion, our data reinforce the notion that HP-NAP has a pivotal role in sustaining a prolonged activation of myeloid cells. |
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Authors:
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Andrea Cappon; Chiara Babolin; Daniela Segat; Laila Cancian; Amedeo Amedei; Federica Calzetti; Marco A Cassatella; Mario M D'Elios; Marina de Bernard |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-01-11 |
Journal Detail:
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Title: Cellular microbiology Volume: 12 ISSN: 1462-5822 ISO Abbreviation: Cell. Microbiol. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-18 Completed Date: 2010-09-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883691 Medline TA: Cell Microbiol Country: England |
Other Details:
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Languages: eng Pagination: 754-64 Citation Subset: IM |
Affiliation:
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Venetian Institute of Molecular Medicine, Padua, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bacterial Proteins
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immunology* Cell Survival Cells, Cultured Helicobacter pylori / immunology* Humans Monocytes / immunology*, microbiology* Neutrophils / immunology*, microbiology* |
| Chemical | |
Reg. No./Substance:
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0/Bacterial Proteins; 0/neutrophil-activating protein A, Helicobacter pylori |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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