Document Detail

Helicobacter pylori colonization in the larynges of patients with hoarseness.
MedLine Citation:
PMID:  18094655     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Vocal nodules and polyps are two common noninfectious causes of hoarseness. Patients with persistent hoarseness often require microscopic laryngeal surgery to excise mass lesions of the larynx despite extensive voice resting and modification of voice use behavior. Helicobacter pylori has recently been reported to present in the upper aerodigestive tract. This study applies the rapid urease test to determine the colonization of Helicobacter pylori in surgical specimens of patients with vocal nodules and polyps. METHODS: In this prospective study, 53 consecutive patients with vocal nodules (n = 20) or vocal polyps (n = 33) were investigated from November 2004 to July 2005. Microscopic laryngeal surgery was performed in all cases. Tissue specimens harvested from the larynx were analyzed using the rapid urease test. RESULTS: The study population consisted of 33 females and 20 males with a mean age of 43.1 +/- 9.9 years. Thirteen (24.5%) of the 53 patients revealed Helicobacter pylori colonization, and all were histopathologically diagnosed with vocal polyps. The difference in incidence of Helicobacter pylori colonization between vocal nodules and vocal polyps was statistically significant (0% [0/20] vs. 39.4% [13/33], P = .001). CONCLUSIONS: Helicobacter pylori often colonizes in the larynxes of patients with vocal polyps. These results indicate the involvement of Helicobacter pylori in vocal polyps. However, the presence of Helicobacter pylori as an etiologic factor in vocal polyps remains inconclusive.
Tuan-Jen Fang; Li-Ang Lee; Hsueh-Yu Li; Chun Yang; Chung-Guei Huang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Laryngoscope     Volume:  118     ISSN:  0023-852X     ISO Abbreviation:  Laryngoscope     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-03-04     Completed Date:  2008-04-24     Revised Date:  2009-09-24    
Medline Journal Info:
Nlm Unique ID:  8607378     Medline TA:  Laryngoscope     Country:  United States    
Other Details:
Languages:  eng     Pagination:  389-93     Citation Subset:  IM    
Department of Otolaryngology, Chang Gung Memorial Hospital, Keelung, Taiwan.
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MeSH Terms
Helicobacter pylori / isolation & purification*
Hoarseness / etiology,  microbiology*
Laryngeal Diseases / complications,  microbiology*
Larynx / microbiology*
Polyps / complications,  microbiology*
Prospective Studies
Vocal Cords / microbiology
Erratum In:
Laryngoscope. 2009 Sep;119(9):1880

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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