| Helicobacter pylori colonization density and gastric acid output in non-ulcer dyspepsia and duodenal ulcer disease. | |
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MedLine Citation:
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PMID: 9631305 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The pattern of intragastric Helicobacter pylori colonization and its density may be determined by parietal cell function. H. pylori bacterial products can inhibit gastric acid secretion from the parietal cell. The aim of this investigation was to study the relationship between acid output and intragastric H. pylori distribution and colonization density in duodenal ulcer (DU) and non-ulcer subjects. The study included 14 patients with active DU, 10 with inactive DU and 10 non-ulcer dyspeptics. METHODS: Acid output studies in response to fasting and maximal pentagastrin stimulation, basal (BAO) and peak (PAO) acid outputs were calculated. A quantitative assessment of H. pylori colonization density in biopsies from five sites of the gastroduodenum in the active ulcer group, and from the antrum in inactive duodenal ulcer and non-ulcer groups. RESULTS: There were negative correlations between total gastroduodenal bacterial colonization density and, PAO (r - 0.87, p = 0.0025) and BAO (r - 0.635, p < 0.02) in the active ulcer group. There were negative correlations between antral H. pylori colonization density and PAO in the active duodenal ulcer (r - 0.7449, p < 0.01) and non-ulcer (r - 0.5837, p < 0.1) groups but not in the inactive duodenal ulcer group (r - 0.1869, p > 0.2). CONCLUSIONS: An equilibrium is reached between gastroduodenal H. pylori colonization density and gastric acid secretory capacity in active duodenal ulcer disease. It is hypothesized that thresholds of bacterial load and acid secretory capacity, in combination, are required for active ulceration in DU disease. |
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Authors:
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P D Mullins; H W Steer |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Helicobacter Volume: 3 ISSN: 1083-4389 ISO Abbreviation: Helicobacter Publication Date: 1998 Jun |
Date Detail:
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Created Date: 1998-08-20 Completed Date: 1998-08-20 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9605411 Medline TA: Helicobacter Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 86-92 Citation Subset: IM |
Affiliation:
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Department of Medicine, Southampton University Hospitals, U.K. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Biopsy Duodenal Ulcer / metabolism*, microbiology* Dyspepsia / metabolism*, microbiology* Endoscopy, Gastrointestinal Female Gastric Acid / secretion* Helicobacter pylori / isolation & purification* Humans Male Middle Aged Statistics, Nonparametric |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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