Document Detail


Helicobacter pylori-negative gastritis: prevalence and risk factors.
MedLine Citation:
PMID:  23147524     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Recent studies using histology alone in select patients have suggested that Helicobacter pylori-negative gastritis may be common. The objective of this study was to investigate the prevalence of H. pylori among individuals with histologic gastritis.
METHODS: Subjects between 40 and 80 years underwent elective esophagogastroduodenoscopy at a VA Medical Center. Gastric biopsies were mapped from seven prespecified sites (two antrum, four corpus, and one cardia) and graded by two gastrointestinal pathologists, using the Updated Sydney System. H. pylori-negative required four criteria: negative triple staining at all seven gastric sites, negative H. pylori culture, negative IgG H. pylori serology, and no previous treatment for H. pylori. Data regarding tobacco smoking, alcohol drinking, nonsteroidal anti-inflammatory drug, and proton pump inhibitor (PPI) use were obtained by questionnaire.
RESULTS: Of the 491 individuals enrolled, 40.7% (200) had gastritis of at least grade 2 in at least one biopsy site or grade 1 in at least two sites. Forty-one (20.5%) had H. pylori-negative gastritis; most (30 or 73.2%) had chronic gastritis, five (12.2%) had active gastritis, and six (14.6%) had both. H. pylori-negative gastritis was approximately equally distributed in the antrum, corpus, and both antrum and corpus. Past and current PPI use was more frequent in H. pylori-negative vs. H. pylori-positive gastritis (68.2% and 53.8%; P=0.06).
CONCLUSIONS: We used multiple methods to define non-H. pylori gastritis and found it in 21% of patients with histologic gastritis. While PPI use is a potential risk factor, the cause or implications of this entity are not known.
Authors:
Helena Nordenstedt; David Y Graham; Jennifer R Kramer; Massimo Rugge; Gordana Verstovsek; Stephanie Fitzgerald; Abeer Alsarraj; Yasser Shaib; Maria E Velez; Neena Abraham; Bhupinderjit Anand; Rhonda Cole; Hashem B El-Serag
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-11-13
Journal Detail:
Title:  The American journal of gastroenterology     Volume:  108     ISSN:  1572-0241     ISO Abbreviation:  Am. J. Gastroenterol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-04     Completed Date:  2013-02-27     Revised Date:  2014-04-15    
Medline Journal Info:
Nlm Unique ID:  0421030     Medline TA:  Am J Gastroenterol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  65-71     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Biopsy
Cross-Sectional Studies
Endoscopy, Digestive System
Female
Gastric Mucosa / microbiology,  pathology
Gastritis / epidemiology,  etiology*,  microbiology,  pathology
Health Surveys
Helicobacter Infections / complications*,  epidemiology,  pathology
Helicobacter pylori / isolation & purification*
Humans
Logistic Models
Male
Middle Aged
Multivariate Analysis
Prevalence
Questionnaires
Risk Factors
Texas / epidemiology
Grant Support
ID/Acronym/Agency:
DK K24-04-107/DK/NIDDK NIH HHS; P30 DK056338/DK/NIDDK NIH HHS; R01 116845//PHS HHS
Comments/Corrections
Comment In:
Am J Gastroenterol. 2013 Jan;108(1):72-4   [PMID:  23287944 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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