| Helicobacter Pylori infection is a significant risk for modified lipid profile in Japanese male subjects. | |
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MedLine Citation:
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PMID: 20610892 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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AIM: Helicobacter Pylori infection was associated with the risk of cardiovascular disease; however, the relation between Helicobacter Pylori infection and the lipid profile has not been fully established. METHODS: We measured anti-Helicobacter Pylori antibody concentration and lipid profiles in 6,289 Japanese subjects aged 21-64 years (5,077 male and 1,212 female). RESULTS: The prevalence of Helicobacter Pylori-seropositive subjects was 46.8% and 39.6% in men and women, respectively. Adjusted mean values of low-density lipoprotein (LDL) cholesterol and high-density lipoprotein (HDL) cholesterol in men were significantly higher and lower in Helicobacter Pylori-seropositive than-negative subjects, respectively, (LDL-cholesterol: 129.0±0.8 vs. 125.3±0.7 mg/dL, p< 0.001, HDL-cholesterol: 54.6±0.3 vs. 56.6±0.3 mg/dL, p< 0.01), whereas these associations were not significant in female subjects. Moreover, the odds ratio of Helicobacter Pylori infection for high LDL-cholesteremia and low HDL-cholesteremia in male subjects was 1.23 (95% CI (confidence interval): 1.08-1.40, p< 0.05) and 1.29 (95% CI: 1.03-1.59, p< 0.05), respectively. Female subjects did not have such associations. CONCLUSIONS: The present study demonstrates that Helicobacter Pylori infection is significantly associated with high LDL-cholesteremia and low HDL-cholesteremia in Japanese male subjects. |
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Authors:
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Hiroki Satoh; Yasuaki Saijo; Eiji Yoshioka; Hiroyuki Tsutsui |
Publication Detail:
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Type: Journal Article Date: 2010-07-02 |
Journal Detail:
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Title: Journal of atherosclerosis and thrombosis Volume: 17 ISSN: 1880-3873 ISO Abbreviation: J. Atheroscler. Thromb. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-11-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9506298 Medline TA: J Atheroscler Thromb Country: Japan |
Other Details:
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Languages: eng Pagination: 1041-8 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Sapporo, Japan. h-satoh@imb.me-h.ne.jp |
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| Comments/Corrections | |
Comment In:
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J Atheroscler Thromb. 2010 Nov 27;17(11):1199-200
[PMID:
21041982
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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