Document Detail


Helicobacter Pylori infection is a significant risk for modified lipid profile in Japanese male subjects.
MedLine Citation:
PMID:  20610892     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
AIM: Helicobacter Pylori infection was associated with the risk of cardiovascular disease; however, the relation between Helicobacter Pylori infection and the lipid profile has not been fully established.
METHODS: We measured anti-Helicobacter Pylori antibody concentration and lipid profiles in 6,289 Japanese subjects aged 21-64 years (5,077 male and 1,212 female).
RESULTS: The prevalence of Helicobacter Pylori-seropositive subjects was 46.8% and 39.6% in men and women, respectively. Adjusted mean values of low-density lipoprotein (LDL) cholesterol and high-density lipoprotein (HDL) cholesterol in men were significantly higher and lower in Helicobacter Pylori-seropositive than-negative subjects, respectively, (LDL-cholesterol: 129.0±0.8 vs. 125.3±0.7 mg/dL, p< 0.001, HDL-cholesterol: 54.6±0.3 vs. 56.6±0.3 mg/dL, p< 0.01), whereas these associations were not significant in female subjects. Moreover, the odds ratio of Helicobacter Pylori infection for high LDL-cholesteremia and low HDL-cholesteremia in male subjects was 1.23 (95% CI (confidence interval): 1.08-1.40, p< 0.05) and 1.29 (95% CI: 1.03-1.59, p< 0.05), respectively. Female subjects did not have such associations.
CONCLUSIONS: The present study demonstrates that Helicobacter Pylori infection is significantly associated with high LDL-cholesteremia and low HDL-cholesteremia in Japanese male subjects.
Authors:
Hiroki Satoh; Yasuaki Saijo; Eiji Yoshioka; Hiroyuki Tsutsui
Publication Detail:
Type:  Journal Article     Date:  2010-07-02
Journal Detail:
Title:  Journal of atherosclerosis and thrombosis     Volume:  17     ISSN:  1880-3873     ISO Abbreviation:  J. Atheroscler. Thromb.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-11-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9506298     Medline TA:  J Atheroscler Thromb     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1041-8     Citation Subset:  IM    
Affiliation:
Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Sapporo, Japan. h-satoh@imb.me-h.ne.jp
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Comment In:
J Atheroscler Thromb. 2010 Nov 27;17(11):1199-200   [PMID:  21041982 ]

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