| Helicases: an overview. | |
| | |
MedLine Citation:
|
PMID: 20225138 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Helicases are essential enzymes involved in all aspects of nucleic acid metabolism including DNA replication, repair, recombination, transcription, ribosome biogenesis and RNA processing, translation, and decay. They occur in vivo as part of molecular complexes that include the components required for each specific step of nucleic acid metabolism. The role of the helicases is to utilize the energy derived from nucleoside triphosphate hydrolysis to translocate along nucleic acid strands, unwind/separate the helical structure of double-stranded nucleic acid, and, in some cases, disrupt protein-nucleic acid interactions. Because of their essential function, helicases are ubiquitous and evolutionary conserved proteins. This chapter briefly highlights helicase structure and activities and provides examples of the helicases involved in nucleic acid metabolism. |
| | |
Authors:
|
Mohamed Abdelhaleem |
Related Documents
:
|
12831908 - Fluorescence in situ hybridisation for the identification and characterisation of proka... 11742648 - Determination of a universal nucleic acid extraction procedure for pcr detection of gas... 19381968 - Immobilization chemistries. 20448968 - Glycosyl-nucleoside-lipid based supramolecular assembly as a nanostructured material wi... 7853868 - Effects on anti-lipid peroxidation of cudrania cochinchinensis var. gerontogea. 811798 - Quinazolines as inhibitors of dihydrofolate reductase. 3. analogs of pteroic and isopte... |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Methods in molecular biology (Clifton, N.J.) Volume: 587 ISSN: 1940-6029 ISO Abbreviation: Methods Mol. Biol. Publication Date: 2010 |
Date Detail:
|
Created Date: 2010-03-12 Completed Date: 2010-05-31 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9214969 Medline TA: Methods Mol Biol Country: United States |
Other Details:
|
Languages: eng Pagination: 1-12 Citation Subset: IM |
Affiliation:
|
Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
DNA
/
metabolism* DNA Helicases* / chemistry, genetics, metabolism DNA Repair DNA, Mitochondrial / metabolism Protein Biosynthesis RNA / metabolism* RNA Helicases* / chemistry, genetics, metabolism RNA Splicing Recombination, Genetic Transcription, Genetic |
| Chemical | |
Reg. No./Substance:
|
0/DNA, Mitochondrial; 63231-63-0/RNA; 9007-49-2/DNA; EC 2.7.7.-/RNA Helicases; EC 3.6.1.-/DNA Helicases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Interactions Between the Immune System and Cancer: A Brief Review of Non-spatial Mathematical Mode...
Next Document: Fluorescent biosensors to investigate helicase activity.