| Helicase: mystery of progression. | |
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MedLine Citation:
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PMID: 17120115 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Helicases mode of unwinding the nucleic acids and translocation along single stranded nucleic acids is still a subject of great curiosity. Based on the energy transduction and electrophilic interactions, we present a model to explain the mode of action of active helicases. This model considers that both strand separation as well as translocation is active processes fueled by NTP hydrolysis. The model proposes that the translocation appears to involve creeping of helicase over the ssNA lattice rather than inchworm movement. |
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Authors:
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Rajneesh Kumar Gaur |
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Publication Detail:
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Type: Journal Article Date: 2006-11-21 |
Journal Detail:
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Title: Molecular biology reports Volume: 34 ISSN: 0301-4851 ISO Abbreviation: Mol. Biol. Rep. Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-07-26 Completed Date: 2008-01-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0403234 Medline TA: Mol Biol Rep Country: Netherlands |
Other Details:
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Languages: eng Pagination: 161-4 Citation Subset: IM |
Affiliation:
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Bioinformatics Center, University of Pune, Pune, India. rajneesh@bioinfo.ernet.in |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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DNA
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chemistry* DNA Helicases / chemistry, metabolism, physiology* Models, Genetic* Nucleic Acid Conformation* Nucleic Acid Denaturation Protein Binding Protein Conformation |
| Chemical | |
Reg. No./Substance:
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9007-49-2/DNA; EC 3.6.1.-/DNA Helicases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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