| Helical computed tomography accurately reports urinary stone composition using attenuation values: in vitro verification using high-resolution micro-computed tomography calibrated to fourier transform infrared microspectroscopy. | |
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MedLine Citation:
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PMID: 15134957 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To assess the ability of helical computed tomography (CT) to differentiate regions of known mineral composition in typical, heterogeneous urinary stones. Interest is substantial in the urologic community in using radiologic imaging to determine accurately the composition of urinary calculi. Recent advances in CT make this a viable prospect, but the heterogeneity of most stones is a complicating factor. METHODS: The ability of micro-CT (a high-resolution laboratory instrument) to identify the mineral composition of stones was confirmed by calibrating micro-CT attenuation values to pure mineral regions of sliced stones using infrared microspectroscopy. Intact human urinary stones were then analyzed by micro-CT, and regions-of-interest of pure mineral were correlated with identical regions-of-interest from quad slice multi-detector row helical CT images. With helical CT, narrow slice widths were used to decrease volume-averaging errors, and bone windows were used so that internal stone structure was visible. RESULTS: When stones were imaged using helical CT at narrow slice widths, mineral-specific regions-of-interest yielded nonoverlapping attenuation values for uric acid (566 to 632 Hounsfield units [HU]), struvite (862 to 944 HU), calcium oxalate (1416 to 1938 HU), and hydroxyapatite (2150 to 2461 HU). CONCLUSIONS: High resolution helical CT yields unique attenuation values for common types of stone mineral, but proper windowing is required to localize regions of homogeneity. The results of this in vitro study suggest that high-resolution helical CT may be able to identify stone composition at patient diagnosis. |
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Authors:
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Chad A Zarse; James A McAteer; Mark Tann; Andre J Sommer; Samuel C Kim; Ryan F Paterson; Erin K Hatt; James E Lingeman; Andrew P Evan; James C Williams |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Urology Volume: 63 ISSN: 1527-9995 ISO Abbreviation: Urology Publication Date: 2004 May |
Date Detail:
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Created Date: 2004-05-11 Completed Date: 2004-10-22 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0366151 Medline TA: Urology Country: United States |
Other Details:
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Languages: eng Pagination: 828-33 Citation Subset: IM |
Affiliation:
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Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202-5120, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Calcium Oxalate
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analysis* Calibration Durapatite / analysis* Feasibility Studies Humans Lithotripsy Tomography, Spiral Computed / methods* Uric Acid / analysis* Urinary Calculi / chemistry*, radiography* |
| Grant Support | |
ID/Acronym/Agency:
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P01 DK43881/DK/NIDDK NIH HHS; R01 DK55674/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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1306-06-5/Durapatite; 25454-23-3/Calcium Oxalate; 69-93-2/Uric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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