Document Detail

Heights and haematology: the story of haemoglobin at altitude.
MedLine Citation:
PMID:  17344565     Owner:  NLM     Status:  MEDLINE    
In order to compensate for the low partial pressure of oxygen at altitude, the human body undergoes a number of physiological changes. A vital component in this process is the increase in the concentration of circulating haemoglobin. The role of HIF-1alpha, erythropoietin and red blood cells in this acclimatisation process is described, together with the fall in plasma volume that increases the concentration of haemoglobin in the early stages of hypoxic exposure.
Jeremy S Windsor; George W Rodway
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Publication Detail:
Type:  Historical Article; Journal Article; Review    
Journal Detail:
Title:  Postgraduate medical journal     Volume:  83     ISSN:  1469-0756     ISO Abbreviation:  Postgrad Med J     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-03-08     Completed Date:  2007-11-07     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  0234135     Medline TA:  Postgrad Med J     Country:  England    
Other Details:
Languages:  eng     Pagination:  148-51     Citation Subset:  IM    
Centre for Aviation, Space and Extreme Environment Medicine (CASE), University College London, Archway Campus, Whittington Hospital, Archway, London N19 5NF, UK.
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MeSH Terms
Acclimatization / physiology*
Altitude Sickness / blood*,  history
Erythropoietin / physiology
Hemoglobins / analysis,  physiology*
History, 17th Century
History, 18th Century
History, 19th Century
History, 20th Century
Hypoxia-Inducible Factor 1, alpha Subunit / physiology
Plasma Volume / physiology
Polycythemia / blood,  history
Reg. No./Substance:
0/Hemoglobins; 0/Hypoxia-Inducible Factor 1, alpha Subunit; 11096-26-7/Erythropoietin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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