Document Detail


Hedonic hot spots in the brain.
MedLine Citation:
PMID:  17079516     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hedonic "liking" for sensory pleasures is an important aspect of reward, and excessive 'liking' of particular rewards might contribute to excessive consumption and to disorders such as obesity. The present review aims to summarize recent advances in the identification of brain substrates for food 'liking' with a focus on opioid hot spots in the nucleus accumbens and ventral pallidum. Drug microinjection studies have shown that opioids in both areas amplify the 'liking' of sweet taste rewards. Modern neuroscience tools such as Fos plume mapping have further identified hedonic hot spots within the accumbens and pallidum, where opioids are especially tuned to magnify 'liking' of food rewards. Hedonic hot spots in different brain structures may interact with each other within the larger functional circuitry that interconnects them. Better understanding of how brain hedonic hot spots increase the positive affective impact of natural sensory pleasures will help characterize the neural mechanisms potentially involved in 'liking' for many rewards.
Authors:
Susana Peciña; Kyle S Smith; Kent C Berridge
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry     Volume:  12     ISSN:  1073-8584     ISO Abbreviation:  Neuroscientist     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-11-02     Completed Date:  2007-02-22     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  9504819     Medline TA:  Neuroscientist     Country:  United States    
Other Details:
Languages:  eng     Pagination:  500-11     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Behavior, Animal
Brain / anatomy & histology,  physiology*
Brain Mapping*
Emotions / physiology*
Globus Pallidus / anatomy & histology,  physiology
Humans
Neural Pathways / physiology
Nucleus Accumbens / anatomy & histology,  physiology
Reward*
Grant Support
ID/Acronym/Agency:
DA015188/DA/NIDA NIH HHS; DC00011/DC/NIDCD NIH HHS; MH63649/MH/NIMH NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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