| Hedgehog signaling and the retina: insights into the mechanisms controlling the proliferative properties of neural precursors. | |
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MedLine Citation:
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PMID: 17079690 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hedgehog signaling has been linked to cell proliferation in a variety of systems; however, its effects on the cell cycle have not been closely studied. In the vertebrate retina, Hedgehog's effects are controversial, with some reports emphasizing increased proliferation and others pointing to a role in cell cycle exit. Here we demonstrate a novel role for Hedgehog signaling in speeding up the cell cycle in the developing retina by reducing the length of G1 and G2 phases. These fast cycling cells tend to exit the cell cycle early. Conversely, retinal progenitors with blocked Hedgehog signaling cycle more slowly, with longer G1 and G2 phases, and remain in the cell cycle longer. Hedgehog may modulate cell cycle kinetics through activation of the key cell cycle activators cyclin D1, cyclin A2, cyclin B1, and cdc25C. These findings support a role for Hedgehog in regulating the conversion from slow cycling stem cells to fast cycling transient amplifying progenitors that are closer to cell cycle exit. |
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Authors:
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Morgane Locker; Michalis Agathocleous; Marcos A Amato; Karine Parain; William A Harris; Muriel Perron |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Genes & development Volume: 20 ISSN: 0890-9369 ISO Abbreviation: Genes Dev. Publication Date: 2006 Nov |
Date Detail:
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Created Date: 2006-11-02 Completed Date: 2006-12-12 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 8711660 Medline TA: Genes Dev Country: United States |
Other Details:
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Languages: eng Pagination: 3036-48 Citation Subset: IM |
Affiliation:
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Laboratoire Gènes, Développement et Neurogenèse, Université Paris XI, UMR Centre national de la Recherche Scientifique (CNRS) 8080, Orsay, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Cycle / genetics Cell Cycle Proteins / agonists, metabolism Cell Differentiation* Cell Proliferation Hedgehog Proteins / antagonists & inhibitors, genetics, physiology* Neurons / cytology, physiology* Retina / cytology, growth & development* Signal Transduction Stem Cells / cytology, physiology* Xenopus |
| Grant Support | |
ID/Acronym/Agency:
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//Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/Cell Cycle Proteins; 0/Hedgehog Proteins |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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