Document Detail


Hedgehog signaling is a principal inducer of Myosin-II-driven cell ingression in Drosophila epithelia.
MedLine Citation:
PMID:  17981140     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cell constriction promotes epithelial sheet invagination during embryogenesis across phyla. However, how this cell response is linked to global patterning information during organogenesis remains unclear. To address this issue, we have used the Drosophila eye and studied the formation of the morphogenetic furrow (MF), which is characterized by cells undergoing a synchronous apical constriction and apicobasal contraction. We show that this cell response relies on microtubules and F-actin enrichment within the apical domain of the constricting cell as well as on the activation of nonmuscle myosin. In the MF, Hedgehog (Hh) signaling is required to promote cell constriction downstream of cubitus interruptus (ci), and, in this context, Ci155 functions redundantly with mad, the main effector of dpp/BMP signaling. Furthermore, ectopically activating Hh signaling in fly epithelia reveals a direct relationship between the duration of exposure to this signaling pathway, the accumulation of activated Myosin II, and the degree of tissue invagination.
Authors:
Douglas Corrigall; Rhian F Walther; Lilia Rodriguez; Pierre Fichelson; Franck Pichaud
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Developmental cell     Volume:  13     ISSN:  1534-5807     ISO Abbreviation:  Dev. Cell     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-11-05     Completed Date:  2008-02-14     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  101120028     Medline TA:  Dev Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  730-42     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Patterning
Cell Movement
Compound Eye, Arthropod / growth & development,  metabolism,  physiology*
DNA-Binding Proteins / metabolism
Drosophila / cytology,  growth & development,  physiology*
Drosophila Proteins / metabolism,  physiology*
Epithelium / growth & development,  physiology
Hedgehog Proteins / physiology*
Morphogenesis
Myosin Type II / physiology*
Signal Transduction
Transcription Factors / metabolism
Grant Support
ID/Acronym/Agency:
MC_U122673973//Medical Research Council
Chemical
Reg. No./Substance:
0/DNA-Binding Proteins; 0/Drosophila Proteins; 0/Hedgehog Proteins; 0/MAD protein, Drosophila; 0/Transcription Factors; 0/ci protein, Drosophila; 0/dpp protein, Drosophila; 149291-21-4/hedgehog protein, Drosophila; EC 3.6.1.-/Myosin Type II

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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