Document Detail

Hedgehog signaling pathway in neural development and disease.
MedLine Citation:
PMID:  17619088     Owner:  NLM     Status:  MEDLINE    
A number of developmental cues underlie proper brain morphogenesis and plasticity. Hedgehog (Hh) signaling pathway plays a critical role in determining proper embryonic patterning and cell fate determination in the central nervous system. Embryonic and adult neural progenitor cells are mostly responsive to Hh signaling, thereby sustaining developmental and tissue repair processes. Hh signaling pathway is finely tuned in order to maintain physiological cell functions during the development of the nervous system and afterwards. Its deregulation is responsible for a number of diseases (e.g. cancer, neurodegenerative disorders). Recently identified Hh pathway regulatory signals involved in the maintenance of nervous tissue shape and their relevance in human pathology are discussed here.
Alberto Gulino; Lucia Di Marcotullio; Elisabetta Ferretti; Enrico De Smaele; Isabella Screpanti
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2007-07-09
Journal Detail:
Title:  Psychoneuroendocrinology     Volume:  32 Suppl 1     ISSN:  0306-4530     ISO Abbreviation:  Psychoneuroendocrinology     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-08-13     Completed Date:  2007-12-06     Revised Date:  2012-02-24    
Medline Journal Info:
Nlm Unique ID:  7612148     Medline TA:  Psychoneuroendocrinology     Country:  England    
Other Details:
Languages:  eng     Pagination:  S52-6     Citation Subset:  IM    
Department of Experimental Medicine and Pathology, University La Sapienza, 324 Viale Regina Elena, 00161 Roma, Italy.
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MeSH Terms
Adult Stem Cells / cytology,  metabolism
Cell Differentiation / physiology*
Embryonic Stem Cells / cytology,  metabolism
Hedgehog Proteins / physiology*
Neoplasms / metabolism
Neurodegenerative Diseases / metabolism
Neurons / cytology,  metabolism*
Second Messenger Systems / physiology
Signal Transduction / physiology*
Grant Support
Reg. No./Substance:
0/Hedgehog Proteins

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