Document Detail


Hedgehog pathway and pediatric nonalcoholic fatty liver disease.
MedLine Citation:
PMID:  23300059     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONCLUSION: The portal/periportal (progenitor) compartment of prepubescent male livers exhibits high Hh pathway activity. This may explain the unique histologic features of pediatric NAFLD because Hh signaling promotes the fibroductular response.
Authors:
Marzena Swiderska-Syn; Ayako Suzuki; Cynthia D Guy; Jeffrey B Schwimmer; Manal F Abdelmalek; Joel E Lavine; Anna Mae Diehl
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2013-04-01
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  57     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-23     Completed Date:  2013-07-05     Revised Date:  2014-05-07    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1814-25     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 American Association for the Study of Liver Diseases.
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MeSH Terms
Descriptor/Qualifier:
Actins / metabolism
Adolescent
Age Factors
Biopsy
Child
Cross-Sectional Studies
Fatty Liver / metabolism,  physiopathology*
Female
Hedgehog Proteins / physiology*
Humans
Keratin-7 / metabolism
Kruppel-Like Transcription Factors / metabolism
Liver / metabolism,  pathology,  physiopathology*
Male
Nuclear Proteins / metabolism
Portal System / metabolism,  pathology
Sex Factors
Signal Transduction / physiology*
Vimentin / metabolism
Grant Support
ID/Acronym/Agency:
R01 DK053792/DK/NIDDK NIH HHS; R01 DK077794/DK/NIDDK NIH HHS; R01-DK053792/DK/NIDDK NIH HHS; R01-DK077794/DK/NIDDK NIH HHS; U01 DK061713/DK/NIDDK NIH HHS; U01 DK061734/DK/NIDDK NIH HHS; U01DK061734/DK/NIDDK NIH HHS; UL1 TR000040/TR/NCATS NIH HHS; UL1TR000040/TR/NCATS NIH HHS; UO1DK061713/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/ACTA2 protein, human; 0/Actins; 0/GLI2 protein, human; 0/Hedgehog Proteins; 0/Keratin-7; 0/Kruppel-Like Transcription Factors; 0/Nuclear Proteins; 0/Vimentin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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