Document Detail

The Hedgehog morphogen in myocardial ischemia-reperfusion injury.
MedLine Citation:
PMID:  20407076     Owner:  NLM     Status:  MEDLINE    
The developmental Hedgehog (Hh) protein family is known to be pivotal in many embryonic patterning events and the number of processes in which Hh plays an essential role is expanding persistently. Recently, it has become clear that the Hh pathway is not only active in the developing embryo but also in the adult organism. For example, Hh has been suggested to salvage ischemia-induced tissue damage although endogenous Hh might be deleterious during the early phase of myocardial ischemia-reperfusion. The current review provides an overview of the history of Hh biology and discusses some novel insights on Hh cell biology. Hh function in pathophysiology as well as recent findings concerning Hh signaling in ischemia models, especially in light of cardiovascular disease, is discussed in more detail and future perspectives are proposed.
Maarten F Bijlsma; C Arnold Spek
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Experimental biology and medicine (Maywood, N.J.)     Volume:  235     ISSN:  1535-3699     ISO Abbreviation:  Exp. Biol. Med. (Maywood)     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-21     Completed Date:  2010-04-28     Revised Date:  2010-07-29    
Medline Journal Info:
Nlm Unique ID:  100973463     Medline TA:  Exp Biol Med (Maywood)     Country:  England    
Other Details:
Languages:  eng     Pagination:  447-54     Citation Subset:  IM    
Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA.
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MeSH Terms
Hedgehog Proteins / genetics,  metabolism*
Myocardial Reperfusion Injury / genetics,  metabolism*
Receptors, G-Protein-Coupled / genetics,  metabolism
Signal Transduction / physiology
Veratrum Alkaloids / metabolism
Reg. No./Substance:
0/Hedgehog Proteins; 0/Receptors, G-Protein-Coupled; 0/Veratrum Alkaloids; 4449-51-8/cyclopamine

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