Document Detail

Hedgehog is involved in prostate basal cell hyperplasia formation and its progressing towards tumorigenesis.
MedLine Citation:
PMID:  17466949     Owner:  NLM     Status:  MEDLINE    
The role of Hedgehog signaling in human basal cell hyperplasia formation and its progressing towards tumorigenesis was investigated. Hedgehog signaling members including PTCH1, GLI1, GLI2, and GLI3 were found co-localized with p63 expression in most hyperplastic basal cells, but rarely in normal basal cells, suggesting Hedgehog involvement in basal cell hyperplasia formation. Both CK-14 and CK-8 markers were found co-localized in the majority of hyperplastic basal cells, but relatively few in the normal basal cells, indicating a Hedgehog-promoted transitory differentiation. Furthermore, CK-14 and PTCH1 were found co-localized with CD44 in the hyerplastic basal cells, in a way similar to the CD44 co-localization with PTCH1 and GLI1 in the cancer cells. Together, the present study indicated Hedgehog involvement in forming basal cell hyperplasia and its progressing towards cancer, presumably by transforming the normal basal stem cells into the cancer stem cells where persistent Hedgehog activation might be mandatory for tumorigenesis.
Bo-Yie Chen; Jer-Yuh Liu; Han-Hsin Chang; Chin-Pao Chang; Wei-Yuh Lo; Wu-Hsien Kuo; Chi-Rei Yang; David P C Lin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-04-20
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  357     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-05-14     Completed Date:  2007-07-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1084-9     Citation Subset:  IM    
Institute of Biochemistry and Biotechnology, Chung Shan Medical University, Taichung 402, Taiwan.
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MeSH Terms
Cell Transformation, Neoplastic / metabolism*,  pathology
Hedgehog Proteins / metabolism*
Prostate / metabolism,  pathology
Prostatic Hyperplasia / metabolism*,  pathology*
Prostatic Neoplasms / metabolism*,  pathology*
Stem Cells / metabolism*,  pathology*
Tumor Cells, Cultured
Reg. No./Substance:
0/Hedgehog Proteins

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