Document Detail


Hedgehog, but not Odd skipped, induces segmental grooves in the Drosophila epidermis.
MedLine Citation:
PMID:  19906854     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The formation of segmental grooves during mid embryogenesis in the Drosophila epidermis depends on the specification of a single row of groove cells posteriorly adjacent to cells that express the Hedgehog signal. However, the mechanism of groove formation and the role of the parasegmental organizer, which consists of adjacent rows of hedgehog- and wingless-expressing cells, are not well understood. We report that although groove cells originate from a population of Odd skipped-expressing cells, this pair-rule transcription factor is not required for their specification. We further find that Hedgehog is sufficient to specify groove fate in cells of different origin as late as stage 10, suggesting that Hedgehog induces groove cell fate rather than maintaining a pre-established state. Wingless activity is continuously required in the posterior part of parasegments to antagonize segmental groove formation. Our data support an instructive role for the Wingless/Hedgehog organizer in cellular patterning.
Authors:
Shai Mulinari; Udo H??cker
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  136     ISSN:  1477-9129     ISO Abbreviation:  Development     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-12     Completed Date:  2009-12-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  England    
Other Details:
Languages:  eng     Pagination:  3875-80     Citation Subset:  IM    
Affiliation:
Department of Experimental Medical Science and Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, BMC B13, 22184 Lund, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Patterning / genetics*
DNA-Binding Proteins / genetics*
Drosophila / embryology,  genetics*,  metabolism*,  ultrastructure
Drosophila Proteins / genetics*
Embryo, Nonmammalian / metabolism,  ultrastructure
Epidermis / metabolism*,  ultrastructure
Hedgehog Proteins / genetics*
Immunohistochemistry
Transcription Factors / genetics*
Chemical
Reg. No./Substance:
0/DNA-Binding Proteins; 0/Drosophila Proteins; 0/Hedgehog Proteins; 0/Transcription Factors; 132191-97-0/odd protein, Drosophila

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