| Hebbian analysis of the transformation of medial entorhinal grid-cell inputs to hippocampal place fields. | |
| | |
MedLine Citation:
|
PMID: 20357069 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The discovery of grid cells in the medial entorhinal cortex (MEC) permits the characterization of hippocampal computation in much greater detail than previously possible. The present study addresses how an integrate-and-fire unit driven by grid-cell spike trains may transform the multipeaked, spatial firing pattern of grid cells into the single-peaked activity that is typical of hippocampal place cells. Previous studies have shown that in the absence of network interactions, this transformation can succeed only if the place cell receives inputs from grids with overlapping vertices at the location of the place cell's firing field. In our simulations, the selection of these inputs was accomplished by fast Hebbian plasticity alone. The resulting nonlinear process was acutely sensitive to small input variations. Simulations differing only in the exact spike timing of grid cells produced different field locations for the same place cells. Place fields became concentrated in areas that correlated with the initial trajectory of the animal; the introduction of feedback inhibitory cells reduced this bias. These results suggest distinct roles for plasticity of the perforant path synapses and for competition via feedback inhibition in the formation of place fields in a novel environment. Furthermore, they imply that variability in MEC spiking patterns or in the rat's trajectory is sufficient for generating a distinct population code in a novel environment and suggest that recalling this code in a familiar environment involves additional inputs and/or a different mode of operation of the network. |
| | |
Authors:
|
Francesco Savelli; James J Knierim |
Related Documents
:
|
7051909 - An expanded cervical cell classification system validated by automated measurements. 22213079 - Protein kinase c mediated extraembryonic endoderm differentiation of human embryonic st... 21673499 - The role of rae1 in nup98 fusion-mediated leukemogenesis. 19502819 - Inhibition of aurora-a results in increased cell death in 3-dimensional culture microen... 21770449 - Single-cell-kinetics approach to compare multidrug resistance-associated membrane trans... 19605219 - Antidromically activated direction selective ganglion cells of the rabbit. 6902969 - The role of plasma transferrin in iron absorption in the rat. 21227389 - Laboratory guidelines for detection, interpretation, and reporting of maternal cell con... 16215259 - Reevaluation of the role of the multidrug-resistant p-glycoprotein in cellular choleste... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-03-31 |
Journal Detail:
|
Title: Journal of neurophysiology Volume: 103 ISSN: 1522-1598 ISO Abbreviation: J. Neurophysiol. Publication Date: 2010 Jun |
Date Detail:
|
Created Date: 2010-06-10 Completed Date: 2010-09-09 Revised Date: 2011-07-28 |
Medline Journal Info:
|
Nlm Unique ID: 0375404 Medline TA: J Neurophysiol Country: United States |
Other Details:
|
Languages: eng Pagination: 3167-83 Citation Subset: IM |
Affiliation:
|
Zanvyl Krieger Mind/Brain Institute, Johns Hopkins University, 338 Krieger Hall, 3400 N. Charles St., Baltimore, MD 21218, USA. fsavelli@jhu.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Action Potentials
/
physiology Algorithms Animals Computer Simulation Efferent Pathways / physiology Entorhinal Cortex / cytology* Hippocampus / physiology* Models, Neurological* Neurons / classification, physiology* Nonlinear Dynamics Space Perception / physiology* Synapses / physiology |
| Grant Support | |
ID/Acronym/Agency:
|
P01 NS-038310/NS/NINDS NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Learning not to generalize: modular adaptation of visuomotor gain.
Next Document: Differences in Na+ conductance density and Na+ channel functional properties between dopamine and GA...