| Heavy metals induce phosphorylation of the Bcl-2 protein by Jun N-terminal kinase. | |
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MedLine Citation:
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PMID: 19007308 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The Bcl-2 protein is one of the key components of biochemical pathways controlling programmed cell death. The function of this protein can be regulated by posttranslational modifications. Phosphorylation of Bcl-2 has been considered to be significantly associated with cell cycle arrest in the G2/M phase of the cell cycle, and with cell death caused by defects of microtubule dynamics. This study shows that phosphorylation of Bcl-2 can be induced by heavy metals due to activation of the Jun N-terminal kinase pathway that is not linked to the G2/M cell cycle arrest. Furthermore, we demonstrate that hyperphosphorylated Bcl-2 protein is a more potent inhibitor of zinc-induced cell death than its hypophosphorylated mutant form. These data suggest that regulation of Bcl-2 protein function by phosphorylation is an important part of cell responses to stress. |
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Authors:
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Eva Ondrousková; Jana Slovácková; Vendula Pelková; Jirina Procházková; Karel Soucek; Petr Benes; Jan Smarda |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biological chemistry Volume: 390 ISSN: 1431-6730 ISO Abbreviation: Biol. Chem. Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2008-12-17 Completed Date: 2009-03-12 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9700112 Medline TA: Biol Chem Country: Germany |
Other Details:
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Languages: eng Pagination: 49-58 Citation Subset: IM |
Affiliation:
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Institute of Experimental Biology, Faculty of Science, Masaryk University, Kotlárská 2, CZ-611 37 Brno, Czech Republic. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis / drug effects Cell Line, Tumor Electrophoresis Gene Expression Regulation, Neoplastic / drug effects Humans JNK Mitogen-Activated Protein Kinases / metabolism* Metals, Heavy / pharmacology* Phosphorylation / drug effects Protein Processing, Post-Translational / drug effects Proto-Oncogene Proteins c-bcl-2 / metabolism* Signal Transduction / drug effects Stress, Physiological / drug effects Zinc / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Metals, Heavy; 0/Proto-Oncogene Proteins c-bcl-2; 7440-66-6/Zinc; EC 2.7.11.24/JNK Mitogen-Activated Protein Kinases |
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