Document Detail


Heavy metals and couple fecundity, the LIFE Study.
MedLine Citation:
PMID:  22309709     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of heavy metals at environmentally relevant concentrations on couple fecundity has received limited study despite ubiquitous exposure. In 2005-2009, couples (n=501) desiring pregnancy and discontinuing contraception were recruited and asked to complete interviews and to provide blood specimens for the quantification of cadmium (μg L(-1)), lead (μg dL(-1)) and mercury (μg L(-1)) using inductively coupled plasma-mass spectrometry. Couples completed daily journals on lifestyle and intercourse along with menstruation and pregnancy testing for women. Couples were followed for 12 months or until pregnant. Fecundability odds ratios (FORs) and 95% confidence intervals (CIs) were estimated adjusting for age, body mass index, cotinine, and serum lipids in relation to female then male exposures. FORs <1 denote a longer time to pregnancy. In adjusted models, reduced FORs were observed for both female cadmium (0.78; 95% CI 0.63-0.97) and male lead (0.85; 95% CI 0.73-0.98) concentrations. When jointly modeling couples' exposures, only male lead concentration significantly reduced the FOR (0.82; 95% CI 0.68, 0.97), though the FOR remained <1 for female cadmium (0.80; 95% CI 0.64, 1.00). This prospective couple based cohort with longitudinal capture of time to pregnancy is suggestive of cadmium and lead's reproductive toxicity at environmentally relevant concentrations.
Authors:
Germaine M Buck Louis; Rajeshwari Sundaram; Enrique F Schisterman; Anne M Sweeney; Courtney D Lynch; Robert E Gore-Langton; Zhen Chen; Sungduk Kim; Kathleen L Caldwell; Dana Boyd Barr
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural     Date:  2012-02-04
Journal Detail:
Title:  Chemosphere     Volume:  87     ISSN:  1879-1298     ISO Abbreviation:  Chemosphere     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-04-16     Completed Date:  2012-08-01     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  0320657     Medline TA:  Chemosphere     Country:  England    
Other Details:
Languages:  eng     Pagination:  1201-7     Citation Subset:  IM    
Copyright Information:
Published by Elsevier Ltd.
Affiliation:
Division of Epidemiology, Statistics and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, MD 20852, United States. louisg@mail.nih.gov
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Body Mass Index
Cadmium / blood
Cohort Studies
Cotinine / analysis
Environmental Pollutants / toxicity*
Female
Fertility / drug effects*
Humans
Lead / blood
Lipids / blood
Longitudinal Studies
Male
Mass Spectrometry
Mercury / blood
Metals, Heavy / toxicity*
Odds Ratio
Pregnancy
Young Adult
Grant Support
ID/Acronym/Agency:
N01-HD-3-3355/HD/NICHD NIH HHS; N01-HD-3-3356/HD/NICHD NIH HHS; N01-HD-3-3358/HD/NICHD NIH HHS; ZIA HD008770-06/HD/NICHD NIH HHS; ZIA HD008770-07/HD/NICHD NIH HHS; ZIA HD008770-08/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Environmental Pollutants; 0/Lipids; 0/Metals, Heavy; 486-56-6/Cotinine; 7439-92-1/Lead; 7439-97-6/Mercury; 7440-43-9/Cadmium
Comments/Corrections

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