| Heavy-chain variable-region sequence from an inulin-binding myeloma protein. | |
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MedLine Citation:
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PMID: 402936 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The entire variable-region sequence of the heavy chain from ABE-47N, a BALB/c inulin-binding myeloma protein, has been determined. This protein is unusual in that the third complementarity region (H3) is extremely short, consisting of at the most three and probably only one amino acid. A comparison of the heavy-chain hypervariable regions from mouse, human, and rabbit proteins shows that the variability in length of H3 is greater than that seen in the first or second hypervariable regions. This variability in H3 length suggests a specialized function for this region. |
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Authors:
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M Vrana; S Rudikoff; M Potter |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biochemistry Volume: 16 ISSN: 0006-2960 ISO Abbreviation: Biochemistry Publication Date: 1977 Mar |
Date Detail:
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Created Date: 1977-05-27 Completed Date: 1977-05-27 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370623 Medline TA: Biochemistry Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1170-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Binding Sites Binding Sites, Antibody* / isolation & purification Chromatography, Affinity Humans Immunoglobulin Heavy Chains* / isolation & purification Immunoglobulin Variable Region* / isolation & purification Inulin* Mice Mice, Inbred BALB C Myeloma Proteins* / isolation & purification Peptide Fragments / analysis Protein Binding Rabbits Species Specificity |
| Chemical | |
Reg. No./Substance:
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0/Binding Sites, Antibody; 0/Immunoglobulin Heavy Chains; 0/Immunoglobulin Variable Region; 0/Myeloma Proteins; 0/Peptide Fragments; 9005-80-5/Inulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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