Document Detail


Heavy charged particle radiobiology: using enhanced biological effectiveness and improved beam focusing to advance cancer therapy.
MedLine Citation:
PMID:  21376738     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ionizing radiation causes many types of DNA damage, including base damage and single- and double-strand breaks. Photons, including X-rays and γ-rays, are the most widely used type of ionizing radiation in radiobiology experiments, and in radiation cancer therapy. Charged particles, including protons and carbon ions, are seeing increased use as an alternative therapeutic modality. Although the facilities needed to produce high energy charged particle beams are more costly than photon facilities, particle therapy has shown improved cancer survival rates, reflecting more highly focused dose distributions and more severe DNA damage to tumor cells. Despite early successes of charged particle radiotherapy, there is room for further improvement, and much remains to be learned about normal and cancer cell responses to charged particle radiation.
Authors:
Christopher Allen; Thomas B Borak; Hirohiko Tsujii; Jac A Nickoloff
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2011-03-03
Journal Detail:
Title:  Mutation research     Volume:  711     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-24     Completed Date:  2011-08-09     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  150-7     Citation Subset:  IM    
Copyright Information:
2011 Elsevier B.V. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
DNA Damage
Gene Expression
Heavy Ions* / therapeutic use
Humans
Neoplasms / radiotherapy*
Protons / therapeutic use*
Radiobiology / instrumentation
Relative Biological Effectiveness
Grant Support
ID/Acronym/Agency:
R01 GM084020/GM/NIGMS NIH HHS; R01 GM084020/GM/NIGMS NIH HHS; R01 GM084020-01A1/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Protons
Comments/Corrections

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