| Heat-stressed rat: effects of atropine, desalivation, or restraint. | |
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MedLine Citation:
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PMID: 7174410 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Heat-stressed rats thermoregulate behaviorally by spreading saliva onto body surfaces and thus lose body water through evaporative cooling. Prior to exploring the role of dehydration in our rat heatstroke model, we sought to compare the abilities of physical restraint, surgical desalivation, and/or atropine to increase the rate of body heat storage by inhibiting body water loss and evaporative cooling during heat exposure. In these experiments, male Sprague-Dawley rats were stressed at an ambient temperature of 41.5 degrees C either in their own cages or in a restraining device until a rectal temperature of 42.6 degrees C was attained. Unrestrained control rats heat-stressed at this temperature lost approximately 8% of body weight (water) during a 258-min exposure. Physical restraint or desalivation reduced both the exposure time and body weight loss by about 72%. Surgically desalivated, heat-stressed rats were observed to engage in voluntary urine-spreading behavior. Maximal heat storage and therefore maximal reduction in exposure time and inhibition of body weight loss to less than 10% of control values were achieved by either physical restraint plus desalivation or by a 500-micrograms dose of atropine. |
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Authors:
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R W Hubbard; C B Matthew; R Francesconi |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of applied physiology: respiratory, environmental and exercise physiology Volume: 53 ISSN: 0161-7567 ISO Abbreviation: J Appl Physiol Publication Date: 1982 Nov |
Date Detail:
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Created Date: 1983-02-14 Completed Date: 1983-02-14 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7801242 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1171-4 Citation Subset: IM; S |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Atropine / pharmacology* Body Temperature Regulation Body Weight Hot Temperature* Male Rats Rats, Inbred Strains Restraint, Physical Salivation* Stress, Physiological / drug therapy, physiopathology* Water Loss, Insensible |
| Chemical | |
Reg. No./Substance:
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51-55-8/Atropine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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