Document Detail

Heat stress protection against mesenteric I/R-induced alterations in intestinal mucosa in rats.
MedLine Citation:
PMID:  12015379     Owner:  NLM     Status:  MEDLINE    
Prior induction of heat shock protein 70 (HSP70) protects against ischemia-reperfusion (I/R) mucosal injury, but the ability of HSP70 to affect I/R-induced alterations in epithelial cell function is unknown. Rats subjected to whole body hyperthermia (41.5-42 degrees C for 6 min) increased HSP70 and heat shock factor 1 mRNA expression, reaching a maximum 2 h after heat stress and declining thereafter. HSP70 production was maximally elevated at 4 h after heat stress and remained elevated until after 12 h. Heat stress alone had no effect on mucosal function except to enhance secretion in response to ACh. Heat stress provided complete morphological protection against I/R-induced mucosal injury but did not confer a similar protection against I/R-induced decreases in mucosal resistance, sodium-linked glucose absorption, or tachykinin-mediated chloride secretion. Heat stress, however, attenuated the I/R-induced suppression of ACh response, and this effect was dependent on enteric nerves. Thus induction of heat shock protein 70 is associated with the preservation of mucosal architecture and attenuation of some specific functional alterations induced by I/R.
Sherry D Fleming; Benjamin W Starnes; Juliann G Kiang; Alexander Stojadinovic; George C Tsokos; Terez Shea-Donohue
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  92     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-05-16     Completed Date:  2002-10-23     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2600-7     Citation Subset:  IM    
Department of Cellular Injury, Walter Reed Army Medical Institute of Research, Silver Spring, Maryland, USA.
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MeSH Terms
Acetylcholine / antagonists & inhibitors,  pharmacology
Chlorides / metabolism
Enteric Nervous System / physiology
Glucose / pharmacokinetics
HSP70 Heat-Shock Proteins / metabolism
Hot Temperature*
Hyperthermia, Induced
Intestinal Mucosa / pathology*,  physiopathology
Ischemia / pathology*,  physiopathology
Rats, Sprague-Dawley
Reperfusion Injury / pathology*,  physiopathology
Splanchnic Circulation*
Stress, Physiological / physiopathology*
Tetrodotoxin / pharmacology
Reg. No./Substance:
0/Chlorides; 0/HSP70 Heat-Shock Proteins; 4368-28-9/Tetrodotoxin; 50-99-7/Glucose; 51-84-3/Acetylcholine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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