| Heat stress enhances mTOR signaling after resistance exercise in human skeletal muscle. | |
| | |
MedLine Citation:
|
PMID: 21222186 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
This study investigated the effect of heat stress (HS) on mammalian target of rapamycin (mTOR) signaling involved in translation initiation after resistance exercise in human skeletal muscle. Eight young male subjects performed four sets of six maximal repetitions of knee extension exercises, with or without HS, in a randomized crossover design. HS was applied to the belly of the vastus lateralis by using a microwave therapy unit prior to and during exercise. Muscle biopsies were taken from the vastus lateralis before, immediately after, and 1 h after exercise. HS significantly increased the phosphorylation of Akt/PKB, mTOR, and ribosomal protein S6 at 1 h after exercise (P < 0.05), and the 4E-BP1 phosphorylation level, which had initially decreased with exercise, had recovered by 1 h after exercise with HS. In addition, the phosphorylation of ribosomal S6 kinase 1 was significantly increased immediately after exercise with HS (P < 0.05). These results indicate that HS enhances mTOR signaling after resistance exercise in human skeletal muscle. |
| | |
Authors:
|
Ryo Kakigi; Hisashi Naito; Yuji Ogura; Hiroyuki Kobayashi; Norio Saga; Noriko Ichinoseki-Sekine; Toshinori Yoshihara; Shizuo Katamoto |
Related Documents
:
|
21195376 - Usefulness of at rest and exercise hemodynamics to detect subclinical myocardial diseas... 2368706 - Skeletal muscle limits the exercise tolerance of renal transplant recipients: effects o... 7759416 - Isotopic determination of glycolytic flux during intense exercise in humans. 11803256 - Do urea/ammonium lactate combinations achieve better skin protection and hydration than... 3942676 - Ventilatory effects of oxygen-enriched mixtures in the dog under althesin anaesthesia. 15657476 - Tricarboxylic-acid-cycle intermediates and cycle endurance capacity. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-1-11 |
Journal Detail:
|
Title: The journal of physiological sciences : JPS Volume: - ISSN: 1880-6562 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2011-1-11 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101262417 Medline TA: J Physiol Sci Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Exercise Physiology, Graduate School of Health and Sports Science, Juntendo University, Inzai, Chiba, 270-1695, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Safety and efficacy of the terminal complement inhibitor eculizumab in Japanese patients with paroxy...
Next Document: A prospective cohort study evaluating associations among delirium, postoperative cognitive dysfuncti...