| Heat stress attenuates the increase in arterial blood pressure during the cold pressor test. | |
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MedLine Citation:
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PMID: 20798269 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The mechanisms by which heat stress impairs the control of blood pressure leading to compromised orthostatic tolerance are not thoroughly understood. A possible mechanism may be an attenuated blood pressure response to a given increase in sympathetic activity. This study tested the hypothesis that whole body heating attenuates the blood pressure response to a non-baroreflex-mediated sympathoexcitatory stimulus. Ten healthy subjects were instrumented for the measurement of integrated muscle sympathetic nerve activity (MSNA), mean arterial blood pressure (MAP), heart rate, sweat rate, and forearm skin blood flow. Subjects were exposed to a cold pressor test (CPT) by immersing a hand in an ice water slurry for 3 min while otherwise normothermic and while heat stressed (i.e., increase core temperature ~0.7°C via water-perfused suit). Mean responses from the final minute of the CPT were evaluated. In both thermal conditions CPT induced significant increases in MSNA and MAP without altering heart rate. Although the increase in MSNA to the CPT was similar between thermal conditions (normothermia: Δ14.0 ± 2.6; heat stress: Δ19.1 ± 2.6 bursts/min; P = 0.09), the accompanying increase in MAP was attenuated when subjects were heat stressed (normothermia: Δ25.6 ± 2.3, heat stress: Δ13.4 ± 3.0 mmHg; P < 0.001). The results demonstrate that heat stress can attenuate the pressor response to a sympathoexcitatory stimulus. |
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Authors:
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Jian Cui; Manabu Shibasaki; David A Low; David M Keller; Scott L Davis; Craig G Crandall |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-08-26 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 109 ISSN: 1522-1601 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-09 Completed Date: 2011-02-18 Revised Date: 2011-11-01 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 1354-9 Citation Subset: IM |
Affiliation:
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Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, TX 75231, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Arteries / physiopathology Blood Flow Velocity Blood Pressure* Cold Temperature* Female Forearm Heart Rate Heat Stress Disorders / physiopathology* Humans Male Muscle, Skeletal / innervation Regional Blood Flow Respiratory Mechanics Skin / blood supply* Sweating Sympathetic Nervous System / physiopathology Time Factors Vascular Resistance Vasoconstriction* |
| Grant Support | |
ID/Acronym/Agency:
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HL-61388/HL/NHLBI NIH HHS; HL-84072/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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