Document Detail


Heat shock treatment prior to myocardial infarction results in reduced ventricular remodeling.
MedLine Citation:
PMID:  19191152     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Heat shock (HS) treatment has been suggested to confer myocardial protection following ischemia. However, the effects of HS on left ventricular (LV) remodeling weeks after infarction have yet to be described. METHODS: Myocardial infarction (MI) was created by coronary ligation in Lewis rats. Two experimental groups of animals were created: HS+MI group (n = 13) and MI group (n = 13). HS treatment consisted of an elevation in core temperature to 42 degrees C for 15 min, 24 hr prior to MI. LV remodeling was assessed by transthoracic echocardiography (day 0, 1, 7, and 28) and by morphometric histology (day 28). RESULTS: There was no significant difference in infarct size (TTC stain 24 hr) between HS+MI and MI groups. Using transthoracic echo there was a significant preservation of LV ejection fraction and fractional shortening in the HS+MI group as compared to MI group (7 and 28 days). Similar trends were seen by histology at 28 days but failed to reach significance. HSP27 expression by myocardial cells was shown to remain up-regulated (at 28 days) in both groups at the edges of the infarct area as compared to control myocardium. CONCLUSIONS: Our findings suggest that HS treatment prior to MI can result in a significant decrease in LV remodeling independent of a reduction in infarct size.
Authors:
Olivier Heimrath; Adam Oxner; Tanya Myers; Jean-Francois Legare
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of investigative surgery : the official journal of the Academy of Surgical Research     Volume:  22     ISSN:  1521-0553     ISO Abbreviation:  J Invest Surg     Publication Date:    2009 Jan-Feb
Date Detail:
Created Date:  2009-02-04     Completed Date:  2009-05-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8809255     Medline TA:  J Invest Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  9-15     Citation Subset:  IM    
Affiliation:
Department of Surgery, Dalhousie University, Halifax, Nova Scotia, Canada.
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MeSH Terms
Descriptor/Qualifier:
Animals
Coronary Vessels / surgery
Echocardiography
HSP27 Heat-Shock Proteins / metabolism
Hot Temperature
Hyperthermia, Induced*
Immunohistochemistry
Ligation
Male
Myocardial Infarction / pathology,  physiopathology*
Myocardium / metabolism,  pathology
Rats
Rats, Inbred Lew
Ventricular Remodeling*
Chemical
Reg. No./Substance:
0/HSP27 Heat-Shock Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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