| Heat shock proteins and their role in heart injury. | |
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MedLine Citation:
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PMID: 12357108 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Heat shock protein (HSP) synthesis arises transiently as a tool to protect cellular homeostasis after exposure to heat and a wide spectrum of stressful and potentially deleterious stimuli. HSPs are "molecular chaperones" that recognize and form a complex with incorrectly folded or denatured proteins, which ultimately leads to correct folding, compartmentalization, or degradation. Accumulating evidence has implicated HSPs as mediators of myocardial protection, particularly in experimental models of ischemia and reperfusion injury. Impaired myocardial performance, which results from many factors, including hypoxia, is one of the main mechanisms responsible for heart failure in the critically ill patient. In this setting, different protective functions have been attributed to HSPs, which include repairing ion channels, restoring redox balance, interacting with nitric oxide-induced protection, inhibiting proinflammatory cytokines, and preventing apoptosis pathway activation. On this basis, novel therapeutic strategies by means of promising pharmacologic interventions and/or gene transfection techniques are being investigated for their potential to enhance HSP expression by myocardial cells, with the goal of improving the outcome of the critically ill patient. |
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Authors:
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Giovanna Delogu; Michele Signore; Andrea Mechelli; Giuseppe Famularo |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current opinion in critical care Volume: 8 ISSN: 1070-5295 ISO Abbreviation: Curr Opin Crit Care Publication Date: 2002 Oct |
Date Detail:
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Created Date: 2002-10-01 Completed Date: 2002-12-06 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 9504454 Medline TA: Curr Opin Crit Care Country: United States |
Other Details:
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Languages: eng Pagination: 411-6 Citation Subset: IM |
Affiliation:
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Department of Anesthesia and Intensive Care, La Sapienza University, Rome, Italy. giovanna.delogu@uniroma1.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Apoptosis
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physiology Heart Injuries / physiopathology* Heat-Shock Proteins / physiology* Heat-Shock Response / physiology Humans Myocardium / metabolism, pathology |
| Chemical | |
Reg. No./Substance:
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0/Heat-Shock Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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