Document Detail

Heat shock proteins 27, 60, 70, 90alpha, and 20S proteasome in on-pump versus off-pump coronary artery bypass graft patients.
MedLine Citation:
PMID:  18154785     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The secretion of heat shock protein (HSP) 27, HSP60, HSP70, HSP90alpha, 20S proteasome, and their correlations to proinflammatory cytokine interleukin-6 is unknown in patients undergoing on-pump versus off-pump coronary artery bypass graft (CABG) operation. METHODS: Forty patients were included in this explorative study (on- versus off-pump CABG, each n = 20). Serum samples were obtained before and 30 minutes, 60 minutes, and 24 hours after CABG operation. Enzyme-linked immunosorbent assay technique was utilized to determine soluble HSP27, 60, 70, and 90alpha, 20S proteasome, and levels of interleukin-6. RESULTS: Serum levels of HSP are increased in patients undergoing on-pump CABG operation as compared with off-pump CABG technique. These differences were highly significant for HSP27, 70, and 90alpha at 60 minutes after initiation of cardiopulmonary bypass (all, p < 0.001). Concentrations of soluble 20S proteasome were increased 24 hours after operation in on- and off-pump CABG patients (p < 0.001) and correlated significantly with the serum content of HSP 27, 70, and 90alpha at 60 minutes after initiation of cardiopulmonary bypass (p < 0.001). No correlation was found when comparing interleukin-6 levels with intravascular leakage of HSP and 20S proteasome after CABG operation. CONCLUSIONS: We conclude from our data that the innate immune system is activated owing to spillage of known immune modulatory and apoptosis-associated proteins after CABG operation.
Tamas Szerafin; Konrad Hoetzenecker; Stefan Hacker; Ambrus Horvath; Andreas Pollreisz; Péterffy Arpád; Andreas Mangold; Tina Wliszczak; Martin Dworschak; Rainald Seitelberger; Ernst Wolner; Hendrik J Ankersmit
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  85     ISSN:  1552-6259     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2007-12-24     Completed Date:  2008-01-25     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  80-7     Citation Subset:  AIM; IM    
Department of Cardiac Surgery, University of Debrecen, Debrecen, Hungary.
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MeSH Terms
Biological Markers / blood
Cardiopulmonary Bypass / methods*
Cohort Studies
Coronary Artery Bypass, Off-Pump / methods*
Coronary Disease / blood*,  diagnosis
Follow-Up Studies
HSP70 Heat-Shock Proteins / blood
HSP90 Heat-Shock Proteins / blood
Heat-Shock Proteins / blood*
Immunity, Innate / physiology*
Interleukin-6 / blood
Middle Aged
Multivariate Analysis
Postoperative Period
Proteasome Endopeptidase Complex / blood*
Sensitivity and Specificity
Treatment Outcome
Reg. No./Substance:
0/Biological Markers; 0/HSP70 Heat-Shock Proteins; 0/HSP90 Heat-Shock Proteins; 0/Heat-Shock Proteins; 0/Interleukin-6; EC Endopeptidase Complex
Comment In:
Ann Thorac Surg. 2008 Jan;85(1):87-8   [PMID:  18154786 ]

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