| Heat shock proteins 27, 60, 70, 90alpha, and 20S proteasome in on-pump versus off-pump coronary artery bypass graft patients. | |
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MedLine Citation:
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PMID: 18154785 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The secretion of heat shock protein (HSP) 27, HSP60, HSP70, HSP90alpha, 20S proteasome, and their correlations to proinflammatory cytokine interleukin-6 is unknown in patients undergoing on-pump versus off-pump coronary artery bypass graft (CABG) operation. METHODS: Forty patients were included in this explorative study (on- versus off-pump CABG, each n = 20). Serum samples were obtained before and 30 minutes, 60 minutes, and 24 hours after CABG operation. Enzyme-linked immunosorbent assay technique was utilized to determine soluble HSP27, 60, 70, and 90alpha, 20S proteasome, and levels of interleukin-6. RESULTS: Serum levels of HSP are increased in patients undergoing on-pump CABG operation as compared with off-pump CABG technique. These differences were highly significant for HSP27, 70, and 90alpha at 60 minutes after initiation of cardiopulmonary bypass (all, p < 0.001). Concentrations of soluble 20S proteasome were increased 24 hours after operation in on- and off-pump CABG patients (p < 0.001) and correlated significantly with the serum content of HSP 27, 70, and 90alpha at 60 minutes after initiation of cardiopulmonary bypass (p < 0.001). No correlation was found when comparing interleukin-6 levels with intravascular leakage of HSP and 20S proteasome after CABG operation. CONCLUSIONS: We conclude from our data that the innate immune system is activated owing to spillage of known immune modulatory and apoptosis-associated proteins after CABG operation. |
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Authors:
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Tamas Szerafin; Konrad Hoetzenecker; Stefan Hacker; Ambrus Horvath; Andreas Pollreisz; Péterffy Arpád; Andreas Mangold; Tina Wliszczak; Martin Dworschak; Rainald Seitelberger; Ernst Wolner; Hendrik J Ankersmit |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The Annals of thoracic surgery Volume: 85 ISSN: 1552-6259 ISO Abbreviation: Ann. Thorac. Surg. Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2007-12-24 Completed Date: 2008-01-25 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 15030100R Medline TA: Ann Thorac Surg Country: Netherlands |
Other Details:
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Languages: eng Pagination: 80-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Cardiac Surgery, University of Debrecen, Debrecen, Hungary. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers
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blood Cardiopulmonary Bypass / methods* Cohort Studies Coronary Artery Bypass, Off-Pump / methods* Coronary Disease / blood*, diagnosis Female Follow-Up Studies HSP70 Heat-Shock Proteins / blood HSP90 Heat-Shock Proteins / blood Heat-Shock Proteins / blood* Humans Immunity, Innate / physiology* Interleukin-6 / blood Male Middle Aged Multivariate Analysis Postoperative Period Probability Proteasome Endopeptidase Complex / blood* Sensitivity and Specificity Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/HSP70 Heat-Shock Proteins; 0/HSP90 Heat-Shock Proteins; 0/Heat-Shock Proteins; 0/Interleukin-6; EC 3.4.25.1/Proteasome Endopeptidase Complex |
| Comments/Corrections | |
Comment In:
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Ann Thorac Surg. 2008 Jan;85(1):87-8
[PMID:
18154786
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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