| Heat shock protein expression in human gliomas. | |
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MedLine Citation:
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PMID: 11205288 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Heat shock proteins (HSP) are cytoprotective, antiapoptotic proteins which may predict clinical prognosis in various types of cancer. Here, we asked whether the differential response to radiochemotherapy and different overall prognosis for astrocytic and oligodendroglial tumours can be accounted for by differences in HSP expression. MATERIAL AND METHODS: We examined aB-crystallin, HSP27, HSP70, HSC70 (HSP73) and HSP90 expression in 44 human gliomas (5 anaplastic and 5 low-grade astrocytomas, 5 anaplastic and 5 low-grade oligodendrogliomas and 24 glioblastomas) by immunohistochemistry. RESULTS: HSP were expressed in the tumour parenchyma of all high-grade and most low-grade gliomas, including oligodendrogliomas. Endothelial cells were more often positive for HSC70 and HSP90, but more often negative for HSP27, in glioblastomas than in the other tumours. HSP were also observed in macrophages/microglial cells, but not in a tumour-specific pattern. CONCLUSION: Different patterns of HSP expression seem not to account for the differential response of these tumours to adjuvant cytotoxic therapy. |
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Authors:
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H M Strik; M Weller; B Frank; M Hermisson; M H Deininger; J Dichgans; R Meyermann |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Anticancer research Volume: 20 ISSN: 0250-7005 ISO Abbreviation: Anticancer Res. Publication Date: 2000 Nov-Dec |
Date Detail:
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Created Date: 2001-02-06 Completed Date: 2001-03-01 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8102988 Medline TA: Anticancer Res Country: Greece |
Other Details:
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Languages: eng Pagination: 4457-62 Citation Subset: IM |
Affiliation:
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Institute of Brain Research, Medical School, University of Tübingen, Calwer Str. 3, D-72076 Tübingen, Germany. herwig.strik@med.uni-tuebingen.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Astrocytoma
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metabolism* Carrier Proteins / metabolism Crystallins / metabolism HSC70 Heat-Shock Proteins HSP70 Heat-Shock Proteins / metabolism HSP90 Heat-Shock Proteins / metabolism Heat-Shock Proteins / metabolism* Humans Neoplasm Proteins / metabolism* Oligodendroglioma / metabolism* Prognosis |
| Chemical | |
Reg. No./Substance:
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0/Carrier Proteins; 0/Crystallins; 0/HSC70 Heat-Shock Proteins; 0/HSP70 Heat-Shock Proteins; 0/HSP90 Heat-Shock Proteins; 0/HSPA8 protein, human; 0/Heat-Shock Proteins; 0/Neoplasm Proteins |
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