Document Detail


Heat shock protein bystander antigens for peptide immunotherapy in autoimmune disease.
MedLine Citation:
PMID:  23199319     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mucosal administration of an antigen eliciting bystander suppression at the site of inflammation results in effective antigen-specific immunotherapy for autoimmune diseases. Heat shock proteins are bystander antigens that are effective in peptide-specific immunotherapy in both experimental and human autoimmune disease. The efficacy of preventive peptide immunotherapy is increased by enhancing peptide-specific immune responses with proinflammatory agents. Combining peptide-specific immunotherapy with general suppression of inflammation may improve its therapeutic effect.
Authors:
E Zonneveld-Huijssoon; S Albani; B J Prakken; F van Wijk
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  171     ISSN:  1365-2249     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-03     Completed Date:  2013-02-19     Revised Date:  2014-01-10    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  20-9     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors. Clinical and Experimental Immunology © 2012 British Society for Immunology.
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MeSH Terms
Descriptor/Qualifier:
Adaptive Immunity
Animals
Antigens / therapeutic use*
Autoimmune Diseases / immunology,  therapy*
Bystander Effect / immunology*
Heat-Shock Proteins / immunology*
Humans
Immune Tolerance / immunology
Immunity, Innate
Immunologic Factors / immunology,  therapeutic use
Immunotherapy*
Mice
Peptides / immunology,  therapeutic use*
Rats
Chemical
Reg. No./Substance:
0/Antigens; 0/Heat-Shock Proteins; 0/Immunologic Factors; 0/Peptides
Comments/Corrections

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