Document Detail


Heat shock protein 72 expression in the right ventricle of patients undergoing congenital cardiac surgery.
MedLine Citation:
PMID:  10925734     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
While heat shock protein (HSP) 72 is known as a stress protein, there have been no reports of HSP 72 expression in patients who have undergone surgery for congenital heart disease. Fourteen patients (7 males and 7 females) who had undergone surgery for congenital heart disease were studied. The ages of the patients ranged from 2 months to 43 years old (mean 6.5 +/- 10.8 years old; median 3.0 years old). The diagnoses were Tetralogy of Fallot in seven, pulmonary atresia with ventricular septal defect (VSD) in three, complex anomalies in three, and VSD in one patient. Histological study and HSP analysis using Western blots and immunostaining with anti-HSP 72 monoclonal antibody were performed for right ventricular muscle samples resected during the surgery. The histological findings showed hypertrophic changes of ventricular cardiomyocytes in all samples studied. Western blots detected HSP 72 expression of various degrees in all specimens. Immunostaining using monoclonal antibody against HSP 72 showed that the protein was present in the nuclei and cytoplasm of cardiomyocytes. In conclusion, although it is difficult to determine the cause of the "stress" that triggers HSP 72 expression in cardiomyocytes, low O2 saturation and pressure overload might act as a "stress", and the only common factor that induced HSP 72 in every sample was hypertrophy.
Authors:
K Nakamura; H Irie; E Fujisawa; H Yoshioka; Y Ninomiya; I Sakuma; S Sano
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta medica Okayama     Volume:  54     ISSN:  0386-300X     ISO Abbreviation:  Acta Med. Okayama     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-11-20     Completed Date:  2000-11-30     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0417611     Medline TA:  Acta Med Okayama     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  103-9     Citation Subset:  IM    
Affiliation:
Department of Cardiovascular Surgery, Okayama University Medical School, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Child
Child, Preschool
Female
HSP72 Heat-Shock Proteins
Heart Defects, Congenital / metabolism*,  surgery*
Heart Septal Defects, Ventricular / complications,  metabolism,  surgery
Heat-Shock Proteins / metabolism*
Humans
Immunologic Techniques
Infant
Male
Myocardium / metabolism*
Pulmonary Atresia / complications,  metabolism*,  surgery
Staining and Labeling
Tetralogy of Fallot / metabolism*,  surgery
Ventricular Function, Right
Chemical
Reg. No./Substance:
0/HSP72 Heat-Shock Proteins; 0/Heat-Shock Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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