| Heat-sensitive liposomes containing cisplatin and localized hyperthermia in treatment of murine tumor. | |
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MedLine Citation:
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PMID: 9834620 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Combined therapy with heat-sensitive liposomes as carriers for drugs and local hyperthermia is thought to improve the local control rate. I studied the antitumor effects and concentrations of CDDP encapsulated in heat-sensitive liposomes (LIP-CDDP) in vivo. LIP-CDDP or CDDP-solution was given to 8 week-old male C3H/He mice bearing SCC VII tumors by tail vein injection, and tumors were heated at 40 degrees C or 42 degrees C. The concentration of LIP-CDDP in blood was significantly higher than that of CDDP-solution. The concentration in tumors after heating at 42 degrees C increased with heating time, but the concentration in tumors without heating or after heating at 40 degrees C did not show these changes. After heating at 42 degrees C, antitumor effects of LIP-CDDP were significantly better than those obtained with the use of CDDP-solution. Heating at 40 degrees C did not alter the antitumor effect of LIP-CDDP. Therefore, LIP-CDDP proved to be very effective when combined with local hyperthermia at 42 degrees C. |
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Authors:
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T Nishita |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Osaka city medical journal Volume: 44 ISSN: 0030-6096 ISO Abbreviation: Osaka City Med J Publication Date: 1998 Jun |
Date Detail:
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Created Date: 1998-12-29 Completed Date: 1998-12-29 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0376413 Medline TA: Osaka City Med J Country: JAPAN |
Other Details:
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Languages: eng Pagination: 73-83 Citation Subset: IM |
Affiliation:
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Department of Radiology, Osaka City University Medical School, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antineoplastic Agents / administration & dosage*, therapeutic use Carcinoma, Squamous Cell / therapy* Cisplatin / administration & dosage*, therapeutic use Drug Carriers Hot Temperature* Hyperthermia, Induced* Liposomes* Male Mice Mice, Inbred C3H Neoplasms, Experimental / therapy |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Drug Carriers; 0/Liposomes; 15663-27-1/Cisplatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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